Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.
- Authors
- Bae, Munhyung; Chung, Beomkoo; Oh, Ki-Bong; Shin, Jongheon; Oh, Dong-Chan
- Issue Date
- Aug-2015
- Publisher
- MDPI
- Keywords
- marine actinomycete; secondary metabolite; hormaomycin; peptide; antibiotic
- Citation
- MARINE DRUGS, v.13, no.8, pp.5187 - 5200
- Journal Title
- MARINE DRUGS
- Volume
- 13
- Number
- 8
- Start Page
- 5187
- End Page
- 5200
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83312
- DOI
- 10.3390/md13085187
- ISSN
- 1660-3397
- Abstract
- Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were discovered from a marine mudflat-derived actinomycete, Streptomyces sp., collected in Mohang, Korea. The planar structures of the hormaomycins, which bear structurally-unique units, such as 4-(Z)-propenylproline, 3-(2-nitrocyclopropyl)alanine, 5-chloro-1-hydroxypyrrol-2-carboxylic acid and -methylphenylalanine, were established as the first natural analogues belonging to the hormaomycin peptide class. The absolute configurations of 1 and 2 were deduced by comparing their CD spectra with that of hormaomycin. These hormaomycins exhibited significant inhibitory effects against various pathogenic Gram-positive and Gram-negative bacteria.
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