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Hormaomycins B and C: New Antibiotic Cyclic Depsipeptides from a Marine Mudflat-Derived Streptomyces sp.

Authors
Bae, MunhyungChung, BeomkooOh, Ki-BongShin, JongheonOh, Dong-Chan
Issue Date
Aug-2015
Publisher
MDPI
Keywords
marine actinomycete; secondary metabolite; hormaomycin; peptide; antibiotic
Citation
MARINE DRUGS, v.13, no.8, pp.5187 - 5200
Journal Title
MARINE DRUGS
Volume
13
Number
8
Start Page
5187
End Page
5200
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83312
DOI
10.3390/md13085187
ISSN
1660-3397
Abstract
Alterations in microbial culture conditions may trigger the production of diverse bioactive secondary metabolites. While applying various culture conditions and monitoring secondary metabolite profiles using LC/MS, hormaomycins B and C (1 and 2) were discovered from a marine mudflat-derived actinomycete, Streptomyces sp., collected in Mohang, Korea. The planar structures of the hormaomycins, which bear structurally-unique units, such as 4-(Z)-propenylproline, 3-(2-nitrocyclopropyl)alanine, 5-chloro-1-hydroxypyrrol-2-carboxylic acid and -methylphenylalanine, were established as the first natural analogues belonging to the hormaomycin peptide class. The absolute configurations of 1 and 2 were deduced by comparing their CD spectra with that of hormaomycin. These hormaomycins exhibited significant inhibitory effects against various pathogenic Gram-positive and Gram-negative bacteria.
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