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Preventive Effect of Anemarrhenae rhizome and Phellodendri cortex on Danazol-Induced in Precocious Puberty in Female Rats and Network Pharmacological Analysis of Active Compounds

Authors
Kim, Kyeong RiTrinh, Tuy AnBaek, Ji YunLee, DahaeLim, SehunKim, JonghyupLee, Won-YungKim, Chang-EopKang, Ki SungLee, Hye Lim
Issue Date
Jan-2022
Publisher
MDPI
Keywords
Anemarrhenae rhizome; Danazol; Network pharmacology; Phellodendri cortex; Precocious puberty
Citation
PLANTS-BASEL, v.11, no.1
Journal Title
PLANTS-BASEL
Volume
11
Number
1
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83322
DOI
10.3390/plants11010023
ISSN
2223-7747
Abstract
Anemarrhenae rhizome and Phellodendri cortex have historically been used for the treatment of precocious puberty (PP) in oriental medicine. Our study aimed to evaluate the effect of APE, a mixture of the extracts from these herbs, against danazol-induced PP in female rats. The offspring were injected danazol to establish the PP model, and then treated with APE daily, and observed for vaginal opening. At the end of the study, the levels of gonadotropic hormones, such as estradiol, follicle-stimulating hormone, and luteinizing hormone, were determined by ELISA. Moreover, the mRNA expression of GnRH, netrin-1, and UNC5C in hypothalamic tissues was determined by real-time PCR. Network pharmacological analysis was performed to predict the active compounds of APE and their potential actions. APE treatment delayed vaginal opening in rats with PP. In addition, APE treatment reduced LH levels and suppressed UNC5C expression. Gene set enrichment analysis revealed that the targets of APE were significantly associated with GnRH signaling and ovarian steroidogenesis pathways. In conclusion, APE may be used as a therapeutic remedy to inhibit the activation of the hypothalamic–pituitary–gonadal axis. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
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Kang, Ki Sung
College of Korean Medicine (Premedical course of Oriental Medicine)
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