The IL-1B Genetic Polymorphism Is Associated with Aspirin-Induced Peptic Ulcers in a Korean Ethnic Group
- Authors
- Cho, Jae Hee; Choi, Ja Sung; Chun, Song Wook; Lee, Sangheun; Han, Ki Jun; Kim, Hee Man
- Issue Date
- May-2016
- Publisher
- EDITORIAL OFFICE GUT & LIVER
- Keywords
- Aspirin; Polymorphism; single nucleotide; Peptic ulcer
- Citation
- GUT AND LIVER, v.10, no.3, pp.362 - 368
- Journal Title
- GUT AND LIVER
- Volume
- 10
- Number
- 3
- Start Page
- 362
- End Page
- 368
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8334
- DOI
- 10.5009/gnl15129
- ISSN
- 1976-2283
- Abstract
- Background/Aims: Single nucleotide polymorphisms (SNPs) are associated with aspirin-induced peptic ulcers. However, SNPs of specific genes vary among races, and data regarding SNPs in the Korean population are scarce. In this study, we aimed to investigate the relationships between SNPs of the COX-1, IL-1 beta, IL-1RN, and TNF genes and aspirin-induced peptic ulcers, as pilot research in a Korean population. Methods: Patients who had been taking low-dose aspirin (100 mg) for at least 4 weeks were prospectively enrolled. DNA was extracted from whole blood, and DNA sequencing was subsequently performed. Results: A total of 48 patients were enrolled (23 peptic ulcer patients vs 25 nonulcer controls). Three exon SNPs (IL-1 beta-581C/T [rs1143627], IL-1 beta-1061C/ T [rs16944], and IL-1RN-1129 [rs4251961]) and one intron SNP (1L-1 beta IVS2+242C/T) were significantly different between the two groups. On the multivariate analysis after adjustments for age and sex, the CC/CT genotypes of IL-1 beta-581C/T, and the CT/TT genotypes of IL-1 beta-1061C/T were positively associated with aspirin-induced peptic ulcers (odds ratio [OR], 4.6, 95% confidence interval [CI], 1.054 to 20.303, p=0.04; OR, 4.6, 95% CI, 1.054 to 20.303, p=0.04). Conclusions: The IL-1 beta-581C/T and IL-1 beta-1061C/T genotypes may be associated with low-dose aspirin-induced peptic ulcers in a Korean ethnic group.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8334)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.