Molecular Weight Determination of Chitosan with Antibacterial Activity Using Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry Analysis
DC Field | Value | Language |
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dc.contributor.author | 이용현 | - |
dc.contributor.author | 박소연 | - |
dc.contributor.author | 황유진 | - |
dc.contributor.author | 박제권 | - |
dc.date.accessioned | 2022-03-27T07:40:17Z | - |
dc.date.available | 2022-03-27T07:40:17Z | - |
dc.date.created | 2022-02-25 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 1598-5032 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83818 | - |
dc.description.abstract | The antibacterial effect of chitosan with different molecular weights was investigated to define their potent biological activity. Both chitosan hydrolysates designated to CTSN-P30 and CTSN-B8 derived from the hydrolysis of high molecular weight chitosan showed significant synergistic antibacterial effects toward Staphylococcus aureus in the presence of 1,3-butylene glycol. The concentration-dependent antimicrobial effect is very important in determining the minimum inhibitory concentration (MIC) of both CTSN-P30 and CTSN-B8. Each MIC50 of CTSN-P30 and CTSNB8 was determined to be about 25 and 50 μg/mL, respectively. Among chitosan hydrolysates, CTSN-P30 can effectively protect the membrane from the penetrating of fine dust which may contain unspecified microorganisms. Also, CTSN-P30, which showed very significant antimicrobial activity, was confirmed to be a hydrolysate containing (GlcNAc)3, and other hydrolysates consisting of (GlcN)5 to (GlcN)15 using matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry analysis. These results demonstrated the feasibility of CTSN-P30 and 1,3-butylene glycol to use as a potent antibacterial and find a dustproof agent for the preparation of various industrial products. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | 한국고분자학회 | - |
dc.relation.isPartOf | Macromolecular Research | - |
dc.title | Molecular Weight Determination of Chitosan with Antibacterial Activity Using Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry Analysis | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000764055800003 | - |
dc.identifier.doi | 10.1007/s13233-022-0013-0 | - |
dc.identifier.bibliographicCitation | Macromolecular Research, v.30, no.2, pp.90 - 98 | - |
dc.identifier.kciid | ART002811809 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85126263607 | - |
dc.citation.endPage | 98 | - |
dc.citation.startPage | 90 | - |
dc.citation.title | Macromolecular Research | - |
dc.citation.volume | 30 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | 이용현 | - |
dc.contributor.affiliatedAuthor | 박소연 | - |
dc.contributor.affiliatedAuthor | 황유진 | - |
dc.contributor.affiliatedAuthor | 박제권 | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | antibacterial effect | - |
dc.subject.keywordAuthor | chitosan | - |
dc.subject.keywordAuthor | fine dust | - |
dc.subject.keywordAuthor | 1 | - |
dc.subject.keywordAuthor | 3-butylene glycol | - |
dc.subject.keywordAuthor | molecular weight. | - |
dc.relation.journalResearchArea | Polymer Science | - |
dc.relation.journalWebOfScienceCategory | Polymer Science | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
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