Abdominal Aortic Calcification and Cardiovascular Outcomes in Chronic Kidney Disease: Findings from KNOW-CKD Study
- Authors
- Suh, Sang Heon; Oh, Tae Ryom; Choi, Hong Sang; Kim, Chang Seong; Bae, Eun Hui; Oh, Kook-Hwan; Lee, Joongyub; Oh, Yun Kyu; Jung, Ji Yong; Ma, Seong Kwon; Kim, Soo Wan
- Issue Date
- Mar-2022
- Publisher
- MDPI
- Keywords
- chronic kidney disease; abdominal aortic calcification; cardiovascular events; all-cause death
- Citation
- JOURNAL OF CLINICAL MEDICINE, v.11, no.5
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- Volume
- 11
- Number
- 5
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/83970
- DOI
- 10.3390/jcm11051157
- ISSN
- 2077-0383
- Abstract
- To investigate the association between abdominal aortic calcification score (AACS) assessed by plain radiograph of the lateral abdomen and the risk of cardiovascular (CV) events in patients with pre-dialysis chronic kidney disease (CKD), a total of 2090 pre-dialysis CKD patients from the Korean Cohort Study for Outcome in Patients with Chronic Kidney Disease (KNOW-CKD) were categorized by AACS into 0, 1-2, 3-4, 5-6, and >= 7. The primary outcome of the study was the composite CV events, defined as a composite of non-fatal CV events and all-cause death. The risk of composite CV events was significantly higher in the subjects with AACS >= 7 (adjusted hazard ratio (HR) 1.888, 95% confidence interval (CI) 1.219 to 2.923), compared to that of the subjects with AACS 0. The risks of fatal and non-fatal CV events (adjusted HR 1.052, 95% CI 1.030 to 1.073) and all-cause death (adjusted HR 1.949, 95% CI 1.073 to 3.539) were also significantly higher in the subjects with AACS >= 7. In conclusion, AACS assessed by plain radiograph is independently associated with adverse CV outcomes in patients with pre-dialysis CKD. A simple radiographic examination of the lateral abdomen may help CV risk stratification in this population.
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