Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of Wasabia japonica
DC Field | Value | Language |
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dc.contributor.author | Park, Jong Eel | - |
dc.contributor.author | Lee, Tae Hyun | - |
dc.contributor.author | Ham, Song Lim | - |
dc.contributor.author | Subedi, Lalita | - |
dc.contributor.author | Hong, Seong Min | - |
dc.contributor.author | Kim, Sun Yeou | - |
dc.contributor.author | Choi, Sang Un | - |
dc.contributor.author | Kim, Chung Sub | - |
dc.contributor.author | Lee, Kang Ro | - |
dc.date.accessioned | 2022-04-19T08:40:23Z | - |
dc.date.available | 2022-04-19T08:40:23Z | - |
dc.date.created | 2022-04-19 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 2076-3921 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84054 | - |
dc.description.abstract | Wasabi (Wasabia japonica (Miq.) Matsum.) is a pungent spice commonly consumed with sushi and sashimi. From the roots of this plant, a new 2-butenolide derivative (1) and 17 previously reported compounds (2-18) were isolated and structurally characterized. Their chemical structures were characterized based on the conventional NMR (H-1 and C-13, COSY, HSQC, and HMBC) and HRESIMS data analysis. All of these phytochemicals (1-18) were evaluated for their antiproliferative effects on the four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and MKN-1), for their inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 microglia cells, and for their nerve growth factor (NGF)-releasing effect from C6 glioma cells. Among the isolated compounds, compound 15 showed powerful antiproliferative activities against A549 and SK-MEL-2 cell lines with IC50 values of 2.10 and 9.08 mu M, respectively. Moreover, the new compound 1 exhibited moderate NO inhibition activity with IC50 value of 45.3 mu M. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | ANTIOXIDANTS | - |
dc.title | Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of Wasabia japonica | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000775988900001 | - |
dc.identifier.doi | 10.3390/antiox11030482 | - |
dc.identifier.bibliographicCitation | ANTIOXIDANTS, v.11, no.3 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85125276248 | - |
dc.citation.title | ANTIOXIDANTS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 3 | - |
dc.contributor.affiliatedAuthor | Subedi, Lalita | - |
dc.contributor.affiliatedAuthor | Hong, Seong Min | - |
dc.contributor.affiliatedAuthor | Kim, Sun Yeou | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Wasabia japonica | - |
dc.subject.keywordAuthor | Brassicaceae | - |
dc.subject.keywordAuthor | 2-butenolide | - |
dc.subject.keywordAuthor | anticancer | - |
dc.subject.keywordAuthor | anti-neuroinflammation | - |
dc.subject.keywordPlus | FATTY-ACIDS | - |
dc.subject.keywordPlus | OXIDATION | - |
dc.subject.keywordPlus | ISOTHIOCYANATES | - |
dc.subject.keywordPlus | INHIBITION | - |
dc.subject.keywordPlus | GLYCOSIDES | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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