Anticancer and Anti-Neuroinflammatory Constituents Isolated from the Roots of Wasabia japonica
- Authors
- Park, Jong Eel; Lee, Tae Hyun; Ham, Song Lim; Subedi, Lalita; Hong, Seong Min; Kim, Sun Yeou; Choi, Sang Un; Kim, Chung Sub; Lee, Kang Ro
- Issue Date
- Mar-2022
- Publisher
- MDPI
- Keywords
- Wasabia japonica; Brassicaceae; 2-butenolide; anticancer; anti-neuroinflammation
- Citation
- ANTIOXIDANTS, v.11, no.3
- Journal Title
- ANTIOXIDANTS
- Volume
- 11
- Number
- 3
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84054
- DOI
- 10.3390/antiox11030482
- ISSN
- 2076-3921
- Abstract
- Wasabi (Wasabia japonica (Miq.) Matsum.) is a pungent spice commonly consumed with sushi and sashimi. From the roots of this plant, a new 2-butenolide derivative (1) and 17 previously reported compounds (2-18) were isolated and structurally characterized. Their chemical structures were characterized based on the conventional NMR (H-1 and C-13, COSY, HSQC, and HMBC) and HRESIMS data analysis. All of these phytochemicals (1-18) were evaluated for their antiproliferative effects on the four human tumor cell lines (A549, SK-OV-3, SK-MEL-2, and MKN-1), for their inhibitory activity on nitric oxide (NO) production in lipopolysaccharide (LPS)-activated BV-2 microglia cells, and for their nerve growth factor (NGF)-releasing effect from C6 glioma cells. Among the isolated compounds, compound 15 showed powerful antiproliferative activities against A549 and SK-MEL-2 cell lines with IC50 values of 2.10 and 9.08 mu M, respectively. Moreover, the new compound 1 exhibited moderate NO inhibition activity with IC50 value of 45.3 mu M.
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