Association between serum osteoprotegerin level and renal prognosis in nondialysis patients with chronic kidney disease in the Korean Cohort Study for Outcomes in Patients with Chronic Kidney Disease (the KNOW-CKD Study)
- Authors
- 오태렴; Myeong, Chana; 송수현; 최홍상; 서상헌; 김창성; 배은희; 정우경; 최규헌; Oh, Kook-Hwan; 마성권; Kim, Soo Wan
- Issue Date
- Mar-2022
- Publisher
- 대한신장학회
- Keywords
- Chronic kidney disease-mineral and bone disorder; Chronic renal insufficiency; Osteoprotegerin; Prognosis; Renal insuffi- ciency
- Citation
- Kidney Research and Clinical Practice, v.41, no.2, pp.200 - 208
- Journal Title
- Kidney Research and Clinical Practice
- Volume
- 41
- Number
- 2
- Start Page
- 200
- End Page
- 208
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84072
- DOI
- 10.23876/j.krcp.21.173
- ISSN
- 2211-9132
- Abstract
- Background: Osteoprotegerin is an important regulator of bone metabolism and vascular calcification. The association between serum osteoprotegerin level and chronic kidney disease (CKD) progression has not been elucidated. We investigated the prognostic value of serum osteoprotegerin levels in nondialysis CKD patients. Methods: We analyzed 2,082 patients enrolled in the Korean Cohort Study for Outcomes in Patients with CKD between 2011 and 2016. Patients were divided into quartiles by their serum osteoprotegerin levels. The primary outcome was the occurrence of ≥1 of the following: dialysis initiation, kidney transplantation, a two-fold increase in serum creatinine level from baseline, or a 50% decrease in the estimated glomerular filtration rate (eGFR). Cox proportional hazard regression models were used to investigate the prognostic value of the serum osteoprotegerin level to CKD progression. Results: The median follow-up period was 48.9 months, and 641 patients (30.8%) experienced the primary outcome. The hazard ratio of serum osteoprotegerin for renal progression in the full extended Cox proportional hazard model was 1.064 (95% confidence interval, 1.041-1.088). Subgroup analyses by age, presence of diabetes, and eGFR showed significant results consistent with the overall analysis results.Conclusion: Serum osteoprotegerin level is independently associated with renal prognosis and could have prognostic importance in CKD progression.
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