Frequencies of glycosylphosphatidylinositol (GPI)-deficient cells using high-sensitivity flow cytometry as per the 2018 ICCS/ESCCA consensus guideline in patients with hematologic malignancy, aplastic anemia, or cytopenia
DC Field | Value | Language |
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dc.contributor.author | Kwoun, Woo-Jae | - |
dc.contributor.author | Lee, Hwan Tae | - |
dc.contributor.author | Ahn, Jeong-Yeal | - |
dc.date.accessioned | 2022-04-25T02:40:03Z | - |
dc.date.available | 2022-04-25T02:40:03Z | - |
dc.date.created | 2022-02-27 | - |
dc.date.issued | 2022-02 | - |
dc.identifier.issn | 1747-4086 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84090 | - |
dc.description.abstract | Objectives We examined the frequencies and sizes of glycosylphosphatidylinositol (GPI)-deficient cells as per the International Clinical Cytometry Society/European Society for Clinical Cell Analysis (ICCS/ESCCA) consensus guidelines for the high-sensitivity detection of GPI-deficient cells. Methods In 2018, the ICCS/ESCCA guidelines for the high-sensitivity detection of GPI-deficient cells were published. We evaluated frequencies and sizes of GPI-deficient red blood cells (RBCs), neutrophils, and monocytes as determined using the ICCS/ESCCA guidelines and Clinical and Laboratory Standards Institute (CLSI) guidelines in patients with a hematologic malignancy, aplastic anemia, or cytopenia. Results A total of 106 (38.7%) patients exhibited GPI deficiency in at least one blood cell lineage. GPI-deficient cells of one or more lineages were found in 62.7% of patients with a hematologic malignancy, 51.1% of patients with aplastic anemia, and 23.4% of patients with cytopenia. GPI-deficient monocytes were most frequently detected in all three groups. By population size, GPI-deficient clones (>1%) in monocytes were mostly detected in patients with a hematologic malignancy or aplastic anemia. Rare cells with GPI deficiency (<0.1%) in monocytes were most common among patients with cytopenia. Conclusion High-sensitive flow cytometry analysis including monocytes may be necessary for patients with a hematologic disorder. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | EXPERT REVIEW OF HEMATOLOGY | - |
dc.title | Frequencies of glycosylphosphatidylinositol (GPI)-deficient cells using high-sensitivity flow cytometry as per the 2018 ICCS/ESCCA consensus guideline in patients with hematologic malignancy, aplastic anemia, or cytopenia | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000755415900001 | - |
dc.identifier.doi | 10.1080/17474086.2022.2038561 | - |
dc.identifier.bibliographicCitation | EXPERT REVIEW OF HEMATOLOGY, v.15, no.2, pp.175 - 181 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85125240018 | - |
dc.citation.endPage | 181 | - |
dc.citation.startPage | 175 | - |
dc.citation.title | EXPERT REVIEW OF HEMATOLOGY | - |
dc.citation.volume | 15 | - |
dc.citation.number | 2 | - |
dc.contributor.affiliatedAuthor | Kwoun, Woo-Jae | - |
dc.contributor.affiliatedAuthor | Ahn, Jeong-Yeal | - |
dc.type.docType | Article; Early Access | - |
dc.subject.keywordAuthor | Paroxysmal nocturnal hemoglobinuria | - |
dc.subject.keywordAuthor | glycosylphosphatidylinositol deficiency | - |
dc.subject.keywordAuthor | high-sensitivity flow cytometry | - |
dc.subject.keywordAuthor | 2018 ICCS | - |
dc.subject.keywordAuthor | ESCCA | - |
dc.subject.keywordAuthor | hematologic disorder | - |
dc.subject.keywordPlus | PAROXYSMAL-NOCTURNAL HEMOGLOBINURIA | - |
dc.subject.keywordPlus | GPI-DEFICIENT CELLS | - |
dc.subject.keywordPlus | MYELODYSPLASTIC SYNDROMES | - |
dc.subject.keywordPlus | ANCHORED PROTEIN | - |
dc.subject.keywordPlus | BLOOD-CELLS | - |
dc.subject.keywordPlus | PNH | - |
dc.subject.keywordPlus | DISORDERS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | FLAER | - |
dc.subject.keywordPlus | CLONES | - |
dc.relation.journalResearchArea | Hematology | - |
dc.relation.journalWebOfScienceCategory | Hematology | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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