An Analysis of the proteomics approach to the glycated peptides of human milk
- Authors
- Cho, Seonghyeon; Park, Jong-Moon; Lee, Hookeun; Song, Jun Hwan; Kang, Nam Mi
- Issue Date
- Feb-2022
- Publisher
- 한국분석과학회
- Keywords
- glycation; advanced glycation end-product; human milk; LC-MS/MS; fertility
- Citation
- 분석과학, v.35, no.1, pp.8 - 14
- Journal Title
- 분석과학
- Volume
- 35
- Number
- 1
- Start Page
- 8
- End Page
- 14
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84194
- DOI
- 10.5806/AST.2022.35.1.8
- ISSN
- 1225-0163
- Abstract
- Many studies have shown that advanced glycation end-products (AGEs) and glycation adducts are significantly linked to aging and disease. Particularly, the level of glycation in human milk is important because the AGE intake is closely related to AGE levels in infants. In this study, we used human milk samples obtained from four primiparae and four multiparae. We isolated proteins using acetone and trichloroacetic acid (TCA) precipitation. A total of 67 glycated proteins and 122 glycated peptides was quantified; among them, 19 glycated peptides were differentially expressed. We confirmed that the degree of glycation differed according to fertility.
The study provides a foundation for using proteomics to evaluate the mother’s milk quality and link between maternal health and human milk quality.
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