Translocator Protein (18 kDa) Polymorphism (rs6971) in the Korean Populationopen access
- Authors
- Lee, Hyon; Noh, Young; Kim, Woo Ram; Seo, Ha-Eun; Park, Hyeon-Mi
- Issue Date
- Apr-2022
- Publisher
- 대한치매학회
- Keywords
- TSPO Protein; Human; Single Nucleotide Polymorphism; Radioactive Tracer; Positron-Emission Tomography; Neurodegenerative Diseases; Neuroinflammatory Diseases
- Citation
- Dementia and Neurocognitive Disorders(대한치매학회지), v.21, no.2, pp.71 - 78
- Journal Title
- Dementia and Neurocognitive Disorders(대한치매학회지)
- Volume
- 21
- Number
- 2
- Start Page
- 71
- End Page
- 78
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84211
- DOI
- 10.12779/dnd.2022.21.2.71
- ISSN
- 1738-1495
- Abstract
- Background and Purpose: The expression of the 18-kDA mitochondrial translocator protein (TSPO) in the brain is an attractive target to study neuroinflammation. However, the binding properties of TSPO ligands are reportedly dependent on genetic polymorphism of the TSPO gene (rs6971). The objective of this study is to investigate the rs6971 gene polymorphism in the Korean population.
Methods: We performed genetic testing on 109 subjects including patients with mild cognitive impairment, Alzheimer’s disease (AD) dementia, non-AD dementia, and cognitively unimpaired participants. Magnetic resonance imaging scans and detailed neuropsychological tests were also performed, and 29 participants underwent 18F-DPA714 PET scans. Exon 4 of the TSPO gene containing the polymorphism rs6971 (Ala or Thr at position 147) was polymerase chain reaction amplified and sequenced using the Sanger method. The identified rs6971 genotype codes (C/C, C/T, or T/T) of the TSPO protein generated high-, mixed-, or low-affinity binding phenotypes (HABs, MABs, and LABs), respectively.
Results: We found that 96.3% of the study subjects were HAB (105 out of 109 subjects), and 3.7% of the subjects were MAB (4 out of 109 subjects). 18F-DPA-714 PET scans showed nonspecific binding to the thalamus and brainstem, and increased tracer uptake throughout the cortex in cognitively impaired patients. The participant with the MAB polymorphism had a higher DPA714 signal throughout the cortex.
Conclusions: The majority of Koreans are HAB (aprox. 96%). Therefore, the polymorphism of the rs6971 gene would have a smaller impact on the availability of second-generation TSPO PET tracers.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84211)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.