Induction Chemotherapy as a Prognostication Index and Guidance for Treatment of Locally Advanced Head and Neck Squamous Cell Carcinoma: the Concept of Chemo-Selection (KCSG HN13-01)
- Authors
- 이윤규; 강은주; 김범석; 최진혁; 김진수; 박건욱; 이경은; 김효정; 이근욱; 김민경; 안희경; 신성훈; 김혜련; 김성배; 윤환정
- Issue Date
- Jan-2022
- Publisher
- 대한암학회
- Keywords
- Locally advanced head and neck squamous cell carcinoma; Induction chemotherapy; Subsequent treatment
- Citation
- Cancer Research and Treatment, v.54, no.1, pp.109 - 117
- Journal Title
- Cancer Research and Treatment
- Volume
- 54
- Number
- 1
- Start Page
- 109
- End Page
- 117
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84258
- DOI
- 10.4143/crt.2020.1329
- ISSN
- 1598-2998
- Abstract
- Purpose Certain patient subgroups who do not respond to induction chemotherapy (IC) show inherent chemoresistance in locally advanced head and neck squamous cell carcinoma (LA-HNSCC). This study aimed to assess the prognostic value of IC, and role of IC in guiding the selection of a definitive locoregional therapy.
Materials and Methods Out of the 445 patients in multi-institutional LA-HNSCC cohort, 158 (36%) receiving IC were enrolled. The study outcome was to assess overall survival (OS) through IC responsiveness and its role to select subsequent treatments.
Results Among 135 patients who completed subsequent treatment following IC, 74% responded to IC (complete response in 17% and partial response in 58%). IC-non-responders showed 4.5 times higher risk of mortality than IC-responders (hazard ratio, 4.52; 95% confidence interval, 2.32 to 8.81; p < 0.001). Among IC-responders, 84% subsequently received definitive concurrent chemoradiotherapy (CCRT) and OS was not differed by surgery or CCRT (p=0.960). Regarding IC-non-responders, 54% received CCRT and 46% underwent surgery, and OS was poor in CCRT (24-month survival rate of 38%) or surgery (24-month survival rate of 63%).
Conclusion Response to IC is a favorable prognostic factor. For IC-responders, either surgery or CCRT achieved similar survival probabilities. For IC-non-responder, multidisciplinary approach was warranted reflecting patients’ preference, morbidity, and prognosis.
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