Beneficial effects of fermented black ginseng and its ginsenoside 20(S)-Rg3 against cisplatin-induced nephrotoxicity in LLC-PK1 cells
- Authors
- Han, Myoung-Sik; Han, Im-Ho; Lee, Dahae; An, Jun Min; Kim, Su-Nam; Shin, Myoung-Sook; Yamabe, Noriko; Hwang, Gwi Seo; Yoo, Hye Hyun; Choi, Suk-Jung; Kang, Ki Sung; Jang, Hyuk-Jai
- Issue Date
- Apr-2016
- Publisher
- KOREAN SOC GINSENG
- Keywords
- cisplatin; ginsenoside 20(S)-Rg3; mitogen-activated protein kinases; nephrotoxicity; Panax ginseng
- Citation
- JOURNAL OF GINSENG RESEARCH, v.40, no.2, pp.135 - 140
- Journal Title
- JOURNAL OF GINSENG RESEARCH
- Volume
- 40
- Number
- 2
- Start Page
- 135
- End Page
- 140
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8433
- DOI
- 10.1016/j.jgr.2015.06.006
- ISSN
- 1226-8453
- Abstract
- Background: Nephrotoxicity is a common side effect of medications. Panax ginseng is one of the best-known herbal medicines, and its individual constituents enhance renal function. Identification of its efficacy and mechanisms of action against drug-induced nephrotoxicity, as well as the specific constituents mediating this effect, have recently emerged as an interesting research area focusing on the kidney protective efficacy of P. ginseng. Methods: The present study investigated the kidney protective effect of fermented black ginseng (FBG) and its active component ginsenoside 20(S)-Rg3 against cisplatin (chemotherapy drug)-induced damage in pig kidney (LLC-PK1) cells. It focused on assessing the role of mitogen-activated protein kinases as important mechanistic elements in kidney protection. Results: The reduced cell viability induced by cisplatin was significantly recovered with FBG extract and ginsenoside 20(S)-Rg3 dose-dependently. The cisplatin-induced elevated protein levels of phosphorylated c-Jun N-terminal kinase (JNK), p53, and cleaved caspase-3 were decreased after cotreatment with FBG extract or ginsenoside 20(S)-Rg3. The elevated percentage of apoptotic LLC-PK1 cells induced by cisplatin treatment was significantly abrogated by cotreatment with FBG and the ginsenoside 20(S)-Rg3. Conclusion: FBG and its major ginsenoside 20(S)-Rg3, ameliorated cisplatin-induced nephrotoxicity in LLC-PK1 cells by blocking the JNK-p53-caspase-3 signaling cascade. Copyright 2015, The Korean Society of Ginseng, Published by Elsevier.
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