Convallaria keiskei as a novel therapeutic alternative for salivary gland cancer treatment by targeting myeloid cell leukemia-1
- Authors
- Lee, Haeng-Eun; Nam, Jeong-Seok; Shin, Ji-Ae; Hong, In-Sun; Yang, In-Hyoung; You, Myung-Jo; Cho, Sung-Dae
- Issue Date
- Apr-2016
- Publisher
- WILEY
- Keywords
- salivary gland cancer; apoptosis; Convallaria keiskei (MECK); myeloid cell leukemia-1 (Mcl-1); extracellular signal-regulated kinases 1/2 (ERK1/2)
- Citation
- HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, v.38, pp.E761 - E770
- Journal Title
- HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
- Volume
- 38
- Start Page
- E761
- End Page
- E770
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8440
- DOI
- 10.1002/hed.24096
- ISSN
- 1043-3074
- Abstract
- Background. Various chemotherapeutic agents have been used largely for the treatment of salivary gland cancer. However, results are disappointing, and these agents can cause some serious side effects. Therefore, recent studies have focused on the possible roles of natural products to overcome these limitations. Methods. Salivary gland cancer cells treated with or without Convallaria keiskei (MECK) for 24 hours. Apoptotic changes were evaluated by live/dead assay, immunoblotting, and expression levels of caspase-3 and B-cell lymphoma-2 family member. Results. MECK significantly inhibited salivary gland cancer growth. At the molecular level, MECK dramatically reduced myeloid cell leukemia-1 (Mcl-1) in a translation-dependent manner and thereby induced apoptosis through Bax/Bid. Furthermore, we found that Mcl-1 could be a potential therapeutic target of MECK-induced apoptosis and its stability is regulated by extracellular signal-regulated kinases 1/2 (ERK1/2) signaling Conclusion. MECK can be used as a safe and efficient therapeutic alternative for the treatment of salivary gland cancer. (C) 2015 Wiley Periodicals, Inc.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8440)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.