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The Potential Crosstalk Between the Brain and Visceral Adipose Tissue in Alzheimer's Development
- Authors
- Thuy Trang Nguyen; Hulme, John; Tuong Kha Vo; Giau Van Vo
- Issue Date
- Jun-2022
- Publisher
- SPRINGER/PLENUM PUBLISHERS
- Keywords
- Alzheimer' s disease; VAT; Crosstalk; Brain; Visceral adipose tissue
- Citation
- NEUROCHEMICAL RESEARCH, v.47, no.6, pp.1503 - 1512
- Journal Title
- NEUROCHEMICAL RESEARCH
- Volume
- 47
- Number
- 6
- Start Page
- 1503
- End Page
- 1512
- ISSN
- 0364-3190
- Abstract
- The bidirectional communication between the brain and peripheral organs have been widely documented, but the impact of visceral adipose tissue (VAT) dysfunction and its relation to structural and functional brain changes have yet to be fully elucidated. This review initially examines the clinical evidence supporting associations between the brain and VAT before visiting the roles of the autonomic nervous system, fat and glucose metabolism, neuroinflammation, and metabolites. Finally, the possible effects and potential mechanisms of the brain-VAT axis on the pathogenesis of Alzheimer's disease are discussed, providing new insights regarding future prevention and therapeutic strategies.
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Related Researcher
- Hulme, John P.
- BioNano Technology (Department of BioNano Technology)