Rational Development of Co-Doped Mesoporous Ceria with High Peroxidase-Mimicking Activity at Neutral pH for Paper-Based Colorimetric Detection of Multiple Biomarkers
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nguyen, Phuong Thy | - |
dc.contributor.author | Lee, Junsang | - |
dc.contributor.author | Cho, Ara | - |
dc.contributor.author | Kim, Min Su | - |
dc.contributor.author | Choi, Daeeun | - |
dc.contributor.author | Han, Jeong Woo | - |
dc.contributor.author | Kim, Moon Il | - |
dc.contributor.author | Lee, Jinwoo | - |
dc.date.accessioned | 2022-06-03T15:40:10Z | - |
dc.date.available | 2022-06-03T15:40:10Z | - |
dc.date.created | 2022-05-23 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 1616-301X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84518 | - |
dc.description.abstract | Peroxidase-mimicking nanozymes have been extensively studied, however, their application is limited by the requirement for an acidic pH. Herein, the development of Co-doped mesoporous cerium oxide (Co-m-ceria) is reported, which operates optimally at a near-neutral pH and exhibits a peroxidase-like catalytic efficiency that is 600-times higher than that of pristine m-ceria. Density functional theory (DFT) calculations for the application of pristine and various metal-doped m-ceria in peroxidase-like reactions under different pH environments are conducted to select Co as the appropriate dopant. The high peroxidase-like activity of Co-m-ceria under neutral conditions and its mesoporous nature enable its application in a one-pot cascade reaction system, wherein biomarkers of oxidative enzymes can be detected without altering the pH. Five different oxidative enzymes are immobilized in the pores of Co-m-ceria at high loadings, followed by incorporation of the enzyme-containing Co-m-ceria in paper microfluidic devices for the convenient and simultaneous detection of multiple biomarkers. The Co-m-ceria-incorporated paper microfluidic device enables the selective and sensitive determination of multiple biomarkers using a smartphone-acquired image. This study demonstrates the potential of the rational design of nanozymes and their application in paper microfluidic devices, laying the groundwork for future applications of nanozymes in point-of-care testing environments. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.relation.isPartOf | Advanced Functional Materials | - |
dc.title | Rational Development of Co-Doped Mesoporous Ceria with High Peroxidase-Mimicking Activity at Neutral pH for Paper-Based Colorimetric Detection of Multiple Biomarkers | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000797626800047 | - |
dc.identifier.doi | 10.1002/adfm.202112428 | - |
dc.identifier.bibliographicCitation | Advanced Functional Materials, v.32, no.21 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85130392906 | - |
dc.citation.title | Advanced Functional Materials | - |
dc.citation.volume | 32 | - |
dc.citation.number | 21 | - |
dc.contributor.affiliatedAuthor | Nguyen, Phuong Thy | - |
dc.contributor.affiliatedAuthor | Kim, Moon Il | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | biosensing | - |
dc.subject.keywordAuthor | density functional theory | - |
dc.subject.keywordAuthor | mesoporous ceria | - |
dc.subject.keywordAuthor | neutral pH peroxidase-like nanozymes | - |
dc.subject.keywordAuthor | paper-based microfluidic devices | - |
dc.subject.keywordPlus | OXYGEN REDUCTION | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | GLUCOSE | - |
dc.subject.keywordPlus | NANOZYME | - |
dc.subject.keywordPlus | H2O2 | - |
dc.subject.keywordPlus | NANOCOMPOSITES | - |
dc.subject.keywordPlus | SENSITIVITY | - |
dc.subject.keywordPlus | GALACTOSE | - |
dc.subject.keywordPlus | OXIDATION | - |
dc.subject.keywordPlus | MECHANISM | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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