Development of hydrazide based fluorescence probe for detection of Al3+ ions and application in live cell image
- Authors
- Anu, D.; Naveen, P.; Rajamanikandan, R.; Kaveri, M., V
- Issue Date
- Jan-2021
- Publisher
- ELSEVIER SCIENCE SA
- Keywords
- Schiff base hydrazide probe; Al3+ detection; DFT calculations; Fluorescence life time decay and bio imaging
- Citation
- JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY, v.405
- Journal Title
- JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
- Volume
- 405
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/84577
- DOI
- 10.1016/j.jphotochem.2020.112921
- ISSN
- 1010-6030
- Abstract
- Development of highly specific and susceptible sensors for aluminium (Al3+ ions) determination in water medium is still a remarkable task. Herein, a fluorescence probe (SCH) is derived from the condensation of salicyaldehyde and carbohydrazide in 2:1 M ratio and promising chemical sensing of Al3+ ions is investigated. Examinations of the emission features of SCH in CH3OH:H2O (1:2, v/v) solution showed excellent turn on behaviour of Al3+ ions, which is due to 1:1 complex formation between SCH and the Al3+ ions at ambient conditions. The lowest limit of detection was estimated by emission titration experiments and found to be 32 nM which is much more 1000-fold lower than that WHO suggested maximum tolerable concentration. The present probe SCH was highly specific for the detection of Al3+ ions over other potential interfering metal cations. Based on the reversible emission behaviour, an INHIBIT logic gate was assembled with EDTA and Al3+ ions as two inputs. In addition, prospective application of SCH as cellular imaging sensor of Al3+ ions in MCF-7 cells was monitored using optical fluorescence microscopic images and real water samples.
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