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Activation of maternal toll-like receptor-2 causes social deficits and memory impairment in female offspring
- Issue Date
- 2-Mar-2016
- Publisher
- LIPPINCOTT WILLIAMS & WILKINS
- Keywords
- cognitive impairment; maternal immune activation; offspring; social interaction; toll-like receptor-2; zymosan
- Citation
- NEUROREPORT, v.27, no.4, pp.224 - 229
- Journal Title
- NEUROREPORT
- Volume
- 27
- Number
- 4
- Start Page
- 224
- End Page
- 229
- ISSN
- 0959-4965
- Abstract
- To study the relevance of the activation of toll-like receptor-2 and abnormal behavioral properties, we introduced prenatal zymosan, a toll-like receptor-2 ligand, to investigate the effect of maternal immunity on offspring behavior. Only female offspring showed impaired social and cognitive function, suggesting that zymosan may influence females' behavior. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.
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Related Researcher
- Choi, Ji Woong
- Pharmacy (Dept.of Pharmacy)