Perilla frutescens Extract Ameliorates Acetylcholinesterase and Trimethyltin Chloride-Induced Neurotoxicity
- Authors
- Choi, Soo Jung; Oh, Seung Sang; Kim, Cho Rong; Kwon, Yoon Kyung; Suh, Soo Hwan; Kim, Jae Kyeom; Park, Gwi Gun; Son, Seung-Yeol; Shin, Dong-Hoon
- Issue Date
- 1-Mar-2016
- Publisher
- MARY ANN LIEBERT, INC
- Keywords
- Alzheimer' s disease; Perilla frutescens; trimethyltin chloride; Rosmarinic acid; Acetylcholinesterase
- Citation
- JOURNAL OF MEDICINAL FOOD, v.19, no.3, pp.281 - 289
- Journal Title
- JOURNAL OF MEDICINAL FOOD
- Volume
- 19
- Number
- 3
- Start Page
- 281
- End Page
- 289
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8470
- DOI
- 10.1089/jmf.2015.3540
- ISSN
- 1096-620X
- Abstract
- One of the critical features of Alzheimer's disease is cognitive dysfunction, which is, in part, due to decreases in acetylcholine (ACh). The ethanol extract of Perilla frutescens was selected for isolating the acetylcholinesterase (AChE) inhibitor based on preliminary screening. In vivo behavioral tests were performed to examine the effects of the P. frutescens extract on trimethyltin chloride-induced impairment of learning and memory in mice. A diet containing P. frutescens extract effectively reversed learning and memory impairment on the Y-maze and passive avoidance tests. To isolate the active compound from the P. frutescens extract, solvent partitioning, silica gel open column chromatography, thin-layer chromatography, and high-performance liquid chromatography were used. The AChE inhibitor was identified as rosmarinic acid.
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