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A t(11;14)(p13;q11.2) in myelofibrosis following polycythemia vera
- Authors
- Jeong, Ji Hun; Ahn, Jeong Yeal; Park, Pil Whan; Seo, Yiel Hea; Seo, Ja Young; Lee, Jae Hoon; Kim, Kyung Hee
- Issue Date
- Mar-2016
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- Post-polycythemia vera myelofibrosis (post-PV MF); t(11; 14)(p13; q11.2)
- Citation
- CANCER GENETICS, v.209, no.3, pp.112 - 116
- Journal Title
- CANCER GENETICS
- Volume
- 209
- Number
- 3
- Start Page
- 112
- End Page
- 116
- ISSN
- 2210-7762
- Abstract
- Chromosomal abnormalities at 14q11, which encodes the T-cell receptor alpha and delta chain genes, are generally specific for T-cell malignancies, and are rarely reported in other malignancies. We report a novel t(11;14)(p13;q11.2) in a patient with myelofibrosis (MF) following polycythemia vera (PV). This 55-year-old male developed post-PV MF 12 years after the initial diagnosis of PV. He had a normal karyotype at polycythemic disease stage, t(11;14)(p13;q11.2) was newly detected at the time of fibrotic transformation. Therefore, it is likely that this clonal chromosomal abnormality was associated with progression of disease.
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Related Researcher
- Park, Pil Whan
- College of Medicine (Department of Medicine)