Novel Animal Model of Spontaneous Cerebral Petechial Hemorrhage Using Focused Ultrasound in Ratsopen access
- Authors
- Yoon, Sang-Youl; Han, Mun; Lee, Chaejin; Lee, Eun-Hee; Kim, Moonsik; Kim, Kyoung-Tae; Hwang, Jeong-Hyun; Na, Sungdae; Park, Juyoung; Park, Ki-Su
- Issue Date
- Jul-2022
- Publisher
- MDPI
- Keywords
- focused ultrasound; blood-brain barrier; acoustic cavitation; ultrasound field stimulation
- Citation
- MEDICINA-LITHUANIA, v.58, no.7
- Journal Title
- MEDICINA-LITHUANIA
- Volume
- 58
- Number
- 7
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85332
- DOI
- 10.3390/medicina58070881
- ISSN
- 1010-660X
- Abstract
- Background and Objectives: Petechial cerebral hemorrhages can be caused by various factors, such as traumas, cerebral infarctions, and aging, and is related to the disruption of the blood-brain barrier or the cellular damage of blood vessels. However, there is no animal model that recapitulates cerebral petechial hemorrhages. Materials and Methods: Here, we implemented a petechial hemorrhage using a novel technology, i.e., microbubble-assisted focused ultrasound (MB + FUS). Results: This method increases the permeability of the blood-brain barrier by directly applying mechanical force to the vascular endothelial cells through cavitation of the microbubbles. Microbubble-enhanced cavitation has the advantage of controlling the degree and location of petechial hemorrhages. Conclusions: We thus generated a preclinical rat model using noninvasive focal MB + FUS. This method is histologically similar to actual petechial hemorrhages of the brain and allows the achievement of a physiologically resembling petechial hemorrhage. In the future, this method shall be considered as a useful animal model for studying the pathophysiology and treatment of petechial cerebral hemorrhages.
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