Mayo imaging classification is a good predictor of rapid progress among Korean patients with autosomal dominant polycystic kidney disease: results from the KNOW-CKD studyopen access
- Authors
- 박혜인; 홍예지; 연정흠; 오국환; 류현진; 김용철; 이준엽; 김영훈; 채동완; 정우경; 안규리; 오윤규
- Issue Date
- Jul-2022
- Publisher
- 대한신장학회
- Keywords
- Autosomal dominant polycystic kidney; Computer-assisted image interpretation; Glomerular filtration rate; Prognosis; Renal insufficiency
- Citation
- Kidney Research and Clinical Practice, v.41, no.4, pp.432 - 441
- Journal Title
- Kidney Research and Clinical Practice
- Volume
- 41
- Number
- 4
- Start Page
- 432
- End Page
- 441
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85366
- DOI
- 10.23876/j.krcp.21.261
- ISSN
- 2211-9132
- Abstract
- Background: Mayo imaging classification (MIC) is a useful biomarker to predict disease progression in autosomal dominant polycystic kidney disease (ADPKD). This study was performed to validate MIC in the prediction of renal outcome in a prospective Korean ADPKD cohort and evaluate clinical parameters associated with rapid disease progression.
Methods: A total of 178 ADPKD patients were enrolled and prospectively observed for an average duration of 6.2 ± 1.9 years. Rapidprogressor was defined as MIC 1C through 1E while slow progressor was defined as 1A through 1B. Renal composite outcome (doubling of serum creatinine, 50% decline of estimated glomerular filtration rate [eGFR], or initiation of renal replacement therapy) as wellas the annual percent change of height-adjusted total kidney volume (mHTKV-α), and eGFR decline (mGFR-α) were compared between groups.
Results: A total of 110 patients (61.8%) were classified as rapid progressors. These patients were younger and showed a higher proportion of male patients. Rapid progressor was an independent predictor for renal outcome (hazard ratio, 4.09; 95% confidence interval, 1.23–13.54; p = 0.02). The mGFR-α was greater in rapid progressors (–3.58 mL/min per year in 1C, –3.7 in 1D, and –4.52 in1E) compared with that in slow progressors (–1.54 in 1A and –2.06 in 1B). The mHTKV-α was faster in rapid progressors (5.3% peryear in 1C, 9.4% in 1D, and 11.7% in 1E) compared with that in slow progressors (1.2% in 1A and 3.8% in 1B).
Conclusion: MIC is a good predictive tool to define rapid progressors in Korean ADPKD patients.
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