Pilot Study of Cystochon® (Cranberry Extract, Chondroitin Sulfate, and Hyaluronic Acid Complex) in Interstitial Cystitis/Bladder Pain Syndrome
- Authors
- Kim, Kwang Taek; Lee, Jeong Woo; Choe, Hyun-Sop
- Issue Date
- Aug-2022
- Publisher
- 대한요로생식기감염학회
- Keywords
- Interstitial cystitis; Bladder pain syndrome; Cranberry; Chondroitin sulfates; Hyaluronic acid
- Citation
- Urogenital Tract Infection, v.17, no.2, pp.36 - 41
- Journal Title
- Urogenital Tract Infection
- Volume
- 17
- Number
- 2
- Start Page
- 36
- End Page
- 41
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85367
- DOI
- 10.14777/uti.2022.17.2.36
- ISSN
- 2465-8243
- Abstract
- Purpose: This study examined whether Cystochon® (cranberry extract, chondroitin sulfate, and hyaluronic acid complex) effectively improves the symptoms and problems of interstitial cystitis/bladder pain syndrome (IC/BPS) patients.
Materials and Methods: From December 2021 to May 2022, the medical records of IC/BPS patients who visited St. Vincent’s Hospital, Kyung Hee University Medical Center, or Gachon University Gil Medical Center were collected. For the treatment of IC/BPS, the patients were given pentosan polysulfate (PPS) for 12 weeks, with Cystochon® then added and maintained for an additional eight weeks.
The OʼLeary–Sant symptom and problem index (Interstitial Cystitis Symptom Index [ICSI], Interstitial Cystitis Problem Index [ICPI]) was used to measure the treatment response.
Results: After 12 weeks of PPS treatment, ICSI and ICPI improved in all patients.
After adding Cystochon® for eight weeks, the ICSI and ICPI indicators improved further. In the ICSI category, significant improvement in symptoms was confirmed in the total ICSI score, particularly in the Q4 (pain-related) questionnaire after adding Cystochon®. In the ICPI category, significant problem improvement was confirmed in the total ICPI score, particularly in the Q1 (frequent urination) and Q4 (pain-related) questionnaires. Although not statistically significant, the remaining indicators generally tended to improve.
Conclusions: The orally administered combination of cranberry extract, chondroitin sulfate, and hyaluronic acid (Cystochon®) may have a clinically positive effect in patients with IC/BPS. Better clinical improvement can be expected when it is added to the PPS treatment, especially in the category of bladder pain.
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