Cognitive Appraisal of Sleep and Brain Activation in Response to Sleep-Related Sounds in Healthy Adultsopen access
- Authors
- Hwang, Yunjee; Lee, Kyung Hwa; Kim, Nambeom; Lee, Jooyoung; Lee, Ha Young; Jeon, Jeong Eun; Lee, Yu Jin; Kim, Seog Ju
- Issue Date
- Aug-2022
- Publisher
- DOVE MEDICAL PRESS LTD
- Keywords
- anterior cingulate cortex; appraisal; functional magnetic resonance imaging; sleep-related sounds
- Citation
- NATURE AND SCIENCE OF SLEEP, v.14, pp.1407 - 1416
- Journal Title
- NATURE AND SCIENCE OF SLEEP
- Volume
- 14
- Start Page
- 1407
- End Page
- 1416
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85619
- DOI
- 10.2147/NSS.S359242
- ISSN
- 1179-1608
- Abstract
- Purpose: Sounds play important roles in promoting and disrupting sleep. How our brain processes sleep-related sounds and individual differences in processing sleep-related sounds must be determined to understand the role of sound in sleep. We investigated neural responses to sleep-related sounds and their associations with cognitive appraisals of sleep.Participants and Methods: Forty-four healthy adults heard sleep-related and neutral sounds during functional magnetic resonance imaging using a 3T scanner. They also completed the Dysfunctional Beliefs and Attitudes about Sleep (DBAS) questionnaire, which was used to assess cognitive appraisals of sleep. We conducted a voxel-wise whole-brain analysis to compare brain activation in response to sleep-related and neutral sounds. We also examined the association between the DBAS score and brain activity in response to sleep-related sounds (vs neutral sounds) using region of interest (ROI) and whole-brain correlation analyses. The ROIs included the anterior cingulate cortex (ACC), anterior insula (AI), and amygdala. Results: The whole-brain analysis revealed increased activation in the temporal regions and decreased activation in the ACC in response to sleep-related sounds compared to neutral sounds. The ROI and whole-brain correlation analyses showed that higher DBAS scores, indicating a negative appraisal of sleep, were significantly correlated with increased activation of the ACC, right medial prefrontal cortex, and brainstem in response to sleep-related sounds.Conclusion: These results indicate that the temporal cortex and ACC, which are implicated in affective sound processing, may play important roles in the processing of sleep-related sounds. The positive association between the neural responses to sleep-related sounds and DBAS scores suggest that negative and dysfunctional appraisals of sleep may be an important factor in individual differences in the processing of sleep-related sounds.
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