Hyperglycemia and Hypoglycemia Are Associated with In-Hospital Mortality among Patients with Coronavirus Disease 2019 Supported with Extracorporeal Membrane Oxygenationopen access
- Authors
- Son, Kuk Hui; Kim, Woong-Han; Kwak, Jae Gun; Choi, Chang-Hyu; Lee, Seok In; Ko, Ui Won; Kim, Hyoung Soo; Lee, Haeyoung; Chung, Euy Suk; Kim, Jae-Bum; Jang, Woo Sung; Jung, Jae Seung; Kim, Jieon; Yoon, Young Kyung; Song, Seunghwan; Sung, Minji; Jang, Myung Hun; Kim, Young Sam; Jeong, In-Seok; Kim, Do Wan; Kim, Tae Yun; Kim, Soon Jin; Kim, Su Wan; Hong, Joonhwa; An, Hyungmi
- Issue Date
- Sep-2022
- Publisher
- MDPI
- Keywords
- COVID-19; diabetes; hyperglycemia; hypoglycemia; extracorporeal membrane
- Citation
- JOURNAL OF CLINICAL MEDICINE, v.11, no.17
- Journal Title
- JOURNAL OF CLINICAL MEDICINE
- Volume
- 11
- Number
- 17
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85670
- DOI
- 10.3390/jcm11175106
- ISSN
- 2077-0383
- Abstract
- Metabolic abnormalities, such as preexisting diabetes or hyperglycemia or hypoglycemia during hospitalization aggravated the severity of COVID-19. We evaluated whether diabetes history, hyperglycemia before and during extracorporeal membrane oxygenation (ECMO) support, and hypoglycemia were risk factors for mortality in patients with COVID-19. This study included data on 195 patients with COVID-19, who were aged >= 19 years and were treated with ECMO. The proportion of patients with diabetes history among nonsurvivors was higher than that among survivors. Univariate Cox regression analysis showed that in-hospital mortality after ECMO support was associated with diabetes history, renal replacement therapy (RRT), and body mass index (BMI) < 18.5 kg/m(2). Glucose at admission >200 mg/dL and glucose levels before ventilator >200 mg/dL were not associated with in-hospital mortality. However, glucose levels before ECMO >200 mg/dL and minimal glucose levels during hospitalization 200 mg/dL before ECMO and minimal glucose <70 mg/dL during hospitalization remained risk factors for in-hospital mortality after adjustment for age, BMI, and RRT. In conclusion, glucose >200 mg/dL before ECMO and minimal glucose level <70 mg/dL during hospitalization were risk factors for in-hospital mortality among COVID-19 patients who underwent ECMO.
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