담낭암 성차에 관한 절제가능성 및 조직병리학적 예후-국내 다기관 연구Multi-Center Study on Gender Difference in Resectability and Pathologic Prognosis of Gallbladder Cancer
- Other Titles
- Multi-Center Study on Gender Difference in Resectability and Pathologic Prognosis of Gallbladder Cancer
- Authors
- 박양태; 강진형; 김재선; 정민규; 김성훈; 조재희; 우상명; 이경주; 김의주; 김효정
- Issue Date
- Jul-2022
- Publisher
- 대한췌장담도학회
- Keywords
- Gender; Age factors; Body mass index; CA-19-9 antigen; Bilirubin
- Citation
- 대한췌담도학회지, v.27, no.3, pp.121 - 127
- Journal Title
- 대한췌담도학회지
- Volume
- 27
- Number
- 3
- Start Page
- 121
- End Page
- 127
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/85777
- ISSN
- 1976-3573
- Abstract
- Background/Aim: In gallbladder cancer (GBC), gender differences in incidence and mortality rates have been reported with geographic variation. However, there is little known about sex-related difference in GBC prognosis. This study compares prognostic factors according to gender for GBC.
Methods: We searched clinicopathological factors in all stages of 952 GBC patients from seven medical centers in Korea. A total of 927 patients were enrolled and surgery with curative resection was performed in 499 patients.
Results: Carbohydrate antigen (≥37 U/mL) was a significant prognostic factor in both females and males (odd ratio [OR], 4.30; 95% confidence interval [CI], 3.13-5.89; p<0.001). Age was a significant factor only in female patients, elderly patients were associated with low resectability and the likelihood of T-stage >2; an independent predictor of poor prognosis via multivariate analysis (OR, 1.03; 95% CI, 1.01-1.05; p=0.005, OR, 1.05; 95% CI, 1.02-1.08; p=0.002). Body mass index (BMI) also showed gender difference, and lower BMI (≤25 kg/m2) was the significant good indicator of multivariate analysis for lymph node metastasis in female patients (OR, 0.42; 95% CI, 0.23-0.77; p=0.005) but, the significant poor indicator of univariate analysis for advanced T-stage in male (OR, 2.79; 95% CI, 1.40-5.54; p=0.003).
Conclusions: These results suggest that there is a possibility of gender difference in GBC prognosis. Age and high BMI were poor prognostic factors for curative resection for female GBC patients.
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