Curcumin/Zeolitic Imidazolate Framework-8 Nanoparticle-Integrated Microneedles for pH-Responsive Treatment of Skin Disorders
DC Field | Value | Language |
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dc.contributor.author | Jung, Seojin | - |
dc.contributor.author | Chang, Seokhee | - |
dc.contributor.author | Kim, Na-Eun | - |
dc.contributor.author | Choi, Seong-O | - |
dc.contributor.author | Song, Yoon-Jae | - |
dc.contributor.author | Yuan, Yue | - |
dc.contributor.author | Kim, Jooyoun | - |
dc.date.accessioned | 2022-11-11T07:40:34Z | - |
dc.date.available | 2022-11-11T07:40:34Z | - |
dc.date.created | 2022-11-08 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 2574-0970 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86039 | - |
dc.description.abstract | A feasible strategy of on-demand drug delivery for the treatment of dermal inflammation under low-pH conditions is proposed, employing zeolitic imidazolate framework-8 (ZIF-8) as a pH-responsive nanoparticle and curcumin (CCM) as a model drug. To overcome the low bioavailability of topically treated drug, a microneedle (MN) form is used to incorporate CCM and ZIF-8. Taking advantage of the fact that ZIF-8 degrades under acidic conditions, CCM is embedded in porous ZIF-8 nanoparticles such that CCM is released when ZIF-8 comes into contact with an acidic dermal fluid at the inflammation site, and this CCM-encapsulated ZIF-8 (CCMZIF) is incorporated into water-dissolvable poly(vinyl pyrrolidone) MN. The ZIF-8 shows a high loading capacity (similar to 40.5%) of CCM through chemical bonding and physical adsorption. From in vitro tests with both a buffered solution and porcine skin, CCM from the CCMZIF MN is released in a higher amount at pH 5.0 than at pH 7.4, demonstrating the capability of the pH-responsive release of the drug when needed at inflammatory sites. The analytical investigation conducted here reveals that an acidic environment triggers the structural degradation of ZIF-8, allowing the release of the chemically bonded CCM. Cytotoxicity and stability tests demonstrate the good biocompatibility and bioavailability of ZIF-8. This study highlights the analytical discussion of the encapsulation and release mechanism of CCM in a ZIF-8-implemented MN drug delivery platform. The results demonstrate an advanced on-demand therapeutic strategy for skin disorder treatment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.relation.isPartOf | ACS APPLIED NANO MATERIALS | - |
dc.title | Curcumin/Zeolitic Imidazolate Framework-8 Nanoparticle-Integrated Microneedles for pH-Responsive Treatment of Skin Disorders | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000860118700001 | - |
dc.identifier.doi | 10.1021/acsanm.2c03884 | - |
dc.identifier.bibliographicCitation | ACS APPLIED NANO MATERIALS, v.5, no.9, pp.13671 - 13679 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85139318224 | - |
dc.citation.endPage | 13679 | - |
dc.citation.startPage | 13671 | - |
dc.citation.title | ACS APPLIED NANO MATERIALS | - |
dc.citation.volume | 5 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Kim, Na-Eun | - |
dc.contributor.affiliatedAuthor | Song, Yoon-Jae | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | ZIF-8 | - |
dc.subject.keywordAuthor | curcumin | - |
dc.subject.keywordAuthor | pH-responsive | - |
dc.subject.keywordAuthor | microneedle | - |
dc.subject.keywordAuthor | release | - |
dc.subject.keywordAuthor | skin | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | CURCUMIN | - |
dc.subject.keywordPlus | DEGRADATION | - |
dc.subject.keywordPlus | SYSTEMS | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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