Curcumin/Zeolitic Imidazolate Framework-8 Nanoparticle-Integrated Microneedles for pH-Responsive Treatment of Skin Disorders
- Authors
- Jung, Seojin; Chang, Seokhee; Kim, Na-Eun; Choi, Seong-O; Song, Yoon-Jae; Yuan, Yue; Kim, Jooyoun
- Issue Date
- Sep-2022
- Publisher
- AMER CHEMICAL SOC
- Keywords
- ZIF-8; curcumin; pH-responsive; microneedle; release; skin
- Citation
- ACS APPLIED NANO MATERIALS, v.5, no.9, pp.13671 - 13679
- Journal Title
- ACS APPLIED NANO MATERIALS
- Volume
- 5
- Number
- 9
- Start Page
- 13671
- End Page
- 13679
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86039
- DOI
- 10.1021/acsanm.2c03884
- ISSN
- 2574-0970
- Abstract
- A feasible strategy of on-demand drug delivery for the treatment of dermal inflammation under low-pH conditions is proposed, employing zeolitic imidazolate framework-8 (ZIF-8) as a pH-responsive nanoparticle and curcumin (CCM) as a model drug. To overcome the low bioavailability of topically treated drug, a microneedle (MN) form is used to incorporate CCM and ZIF-8. Taking advantage of the fact that ZIF-8 degrades under acidic conditions, CCM is embedded in porous ZIF-8 nanoparticles such that CCM is released when ZIF-8 comes into contact with an acidic dermal fluid at the inflammation site, and this CCM-encapsulated ZIF-8 (CCMZIF) is incorporated into water-dissolvable poly(vinyl pyrrolidone) MN. The ZIF-8 shows a high loading capacity (similar to 40.5%) of CCM through chemical bonding and physical adsorption. From in vitro tests with both a buffered solution and porcine skin, CCM from the CCMZIF MN is released in a higher amount at pH 5.0 than at pH 7.4, demonstrating the capability of the pH-responsive release of the drug when needed at inflammatory sites. The analytical investigation conducted here reveals that an acidic environment triggers the structural degradation of ZIF-8, allowing the release of the chemically bonded CCM. Cytotoxicity and stability tests demonstrate the good biocompatibility and bioavailability of ZIF-8. This study highlights the analytical discussion of the encapsulation and release mechanism of CCM in a ZIF-8-implemented MN drug delivery platform. The results demonstrate an advanced on-demand therapeutic strategy for skin disorder treatment.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 바이오나노대학 > 생명과학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86039)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.