Mulberry (Morus alba L.) Leaf Extract and 1-Deoxynojirimycin Improve Skeletal Muscle Insulin Resistance via the Activation of IRS-1/PI3K/Akt Pathway in db/db Mice
- Authors
- Kang, Chae-Won; Park, Miey; Lee, Hae-Jeung
- Issue Date
- Oct-2022
- Publisher
- MDPI
- Keywords
- 1-deoxynojirimycin; db/db mice; IRS-1/PI3K/Akt pathway; Morus albaL; skeletal muscle; type 2 diabetes mellitus
- Citation
- LIFE-BASEL, v.12, no.10
- Journal Title
- LIFE-BASEL
- Volume
- 12
- Number
- 10
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86098
- DOI
- 10.3390/life12101630
- ISSN
- 0024-3019
2075-1729
- Abstract
- Mulberry (Morus alba L.) leaves have been used to lower blood glucose in patients with diabetes. We evaluated the effects of mulberry leaves extract (MLE) and 1-deoxynojirimycin (1-DNJ) in improving insulin resistance through the activation of the IRS-1/PI3K/Akt pathway in the skeletal muscle of db/db mice. Histological analysis revealed an amelioration of muscle deformation and increased muscle fiber size. MLE and 1-DNJ positively raised the protein expression of related glucose uptake and increased the translocation of glucose transporter type 4 (GLUT4) to the membrane. Furthermore, MLE and 1-DNJ activated the IRS-1/PI3K/Akt pathway in the skeletal muscle and, subsequently, modulated the protein levels of glycogen synthase kinase-3beta (GSK-3 beta) and glycogen synthase (GS), leading to elevated muscle glycogen content. These findings suggest that MLE and 1-DNJ supplementation improves insulin resistance by modulating the insulin signaling pathway in the skeletal muscle of db/db mice.
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