Anti-inflammatory effects of Saururus chinensis aerial parts in murine macrophages via induction of heme oxygenase-1
- Authors
- Meng, Xue; Kim, Inhye; Jeong, Yong Joon; Cho, Young Mi; Kang, Se Chan
- Issue Date
- Feb-2016
- Publisher
- SAGE PUBLICATIONS LTD
- Keywords
- Saururus chinensis; sauchinone; anti-inflammation; Heme oxygenase-1; phosphorylation of signal transducers and activators of transcription 1; nuclear factor-kappa B
- Citation
- EXPERIMENTAL BIOLOGY AND MEDICINE, v.241, no.4, pp.396 - 408
- Journal Title
- EXPERIMENTAL BIOLOGY AND MEDICINE
- Volume
- 241
- Number
- 4
- Start Page
- 396
- End Page
- 408
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8627
- DOI
- 10.1177/1535370215614657
- ISSN
- 1535-3702
- Abstract
- Saururus chinensis (Lour.) Baill. is a perennial plant distributed throughout Northeast Asia and its roots have been widely used as a traditional medicine for hepatitis, asthma, pneumonia, and gonorrhea. This study was designed to investigate the anti-inflammatory activity of an extract of S. chinensis of the aerial parts (rather than the root), and the signaling pathway responsible for this effect in lipopolysaccharide-stimulated murine macrophages. The subfraction 4 (SCF4) from the n-hexane layer of the ethanol extract of the aerial parts of S. chinensis exhibited the highest nitrite-inhibitory activity. SCF4 significantly inhibited the production of nitrite and the expression of pro-inflammatory mediators via heme oxygenase-1 upregulation. SCF4 caused significant phosphorylation of p38 MAPK and Akt, which subsequently induced the nuclear translocation of p-p65 nuclear factor-kappa B and Nrf2. SCF4 also suppressed the phosphorylation of signal transducers and activators of transcription 1 (p-STAT1). The heme oxygenase-1 inhibitor zinc protoporphyrin attenuated the inhibitory effect of SCF4 on lipopolysaccharide-stimulated nitrite production and expression of inflammatory mediators, tumor necrosis factor alpha, and p-STAT1. We identified sauchinone as the active compound in S. chinensis extract and SCF4. Sauchinone was shown to significantly inhibit nitrite production and inflammatory mediators expression via heme oxygenase-1 upregulation. These results suggest that S. chinensis extract, SCF4, and its active compound, sauchinone, could be used as an anti-inflammatory agent.
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