Perylene-Derived Hydrophilic Carbon Dots with Polychromatic Emissions as Superior Bioimaging and NIR-Responsive Photothermal Bactericidal Agentopen access
- Authors
- Moniruzzaman, Md; Dutta, Sayan Deb; Lim, Ki-Taek; Kim, Jongsung
- Issue Date
- Oct-2022
- Publisher
- AMER CHEMICAL SOC
- Citation
- ACS OMEGA, v.7, no.42, pp.37388 - 37400
- Journal Title
- ACS OMEGA
- Volume
- 7
- Number
- 42
- Start Page
- 37388
- End Page
- 37400
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86274
- DOI
- 10.1021/acsomega.2c04130
- ISSN
- 2470-1343
- Abstract
- Little progress has been achieved on the synthesis of hydrophilic carbon dots (CDs), derived from polycyclic aromatic hydrocarbons, as an excellent photothermal agent. In this study, a strategy was developed to synthesize highly photoluminescent greenish-yellow emissive CDs based on nitration followed by hydrothermal carbonization of the polycyclic aromatic hydrocarbon precursor, perylene. The perylene-derived CDs (PY-CDs) exhibited an excellent NIR-light (808 nm) harvesting property toward high photothermal conversion efficiency (PCE = similar to 56.7%) and thus demonstrated remarkable NIR-light responsive photothermal bactericidal performance. Furthermore, these fluorescent PY-CD nanoprobes displayed excitation-dependent polychromatic emissions in the range of 538-600 nm, with the maximum emission at 538 nm. This enables intense multicolor biological imaging of cellular substances with long-term photostability, nontoxicity, and effective subcellular distribution. The bactericidal action of PY-CDs is likely due to the elevated reactive oxygen species amplification in cooperation with the hyperthermia effect. This study offers a potential substitute for multicolor imaging-guided metal-free carbon-based photothermal therapy.
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