Ocular Distribution and Pharmacokinetics of 8-Oxo-2 '-Deoxyguanosine: A Novel Therapeutic Candidate of Ocular Surface Diseases
DC Field | Value | Language |
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dc.contributor.author | Chung, Hyewon | - |
dc.contributor.author | Ha, Yuseung | - |
dc.contributor.author | Kim, Yong Ho | - |
dc.contributor.author | Kim, Dong Hyun | - |
dc.contributor.author | Shin, Dongseong | - |
dc.date.accessioned | 2022-12-22T06:40:07Z | - |
dc.date.available | 2022-12-22T06:40:07Z | - |
dc.date.created | 2022-12-12 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 1080-7683 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86305 | - |
dc.description.abstract | Purpose: This study evaluated the ocular distribution and plasma pharmacokinetics (PKs) of 8-oxo-2 '-deoxyguanosine (8-oxo-dG) in rabbits and rats, respectively.Methods: A test formulation containing radiolabeled [(14) C]8-oxo-dG and unlabeled 8-oxo-dG was ocularly administered to rabbits as a single dose of 1 mg per body and intravenously injected to rats as a single dose of 5 mg/kg. The ocular distribution of [(14) C]8-oxo-dG was evaluated using autoradiography until 48 h postdose. Plasma radioactivity in rabbits and rats was determined until 72 and 168 h, respectively.Results: After ocular instillation, [(14) C]8-oxo-dG distributed into ocular tissues, and high radioactivity concentrations were observed in the ciliary body, conjunctiva, and cornea. The maximum plasma concentration (C-max) and area under the concentration-time curve (AUC(0-t)) were highest in the ciliary body and conjunctiva, respectively. In the conjunctiva, cornea, and aqueous humor, time to reach C-max (T-max) was 0.5 h, and the half-lives were 11.2, 30.2, and 15.1 h, respectively. The radioactivity of [(14) C]8-oxo-dG in plasma of rabbits displayed a double-peak phenomenon with the second peak considered as C-max (37.9 +/- 3.1 ng eq./mL) occurring 24 h postdose. After systemic exposure of [(14) C]8-oxo-dG in rats, a rapid decline in the initial phase and a terminal half-life of 56.1 +/- 31.3 h were observed.Conclusions: Rapid ocular distribution and high concentrations in anterior ocular tissues with minimal systemic exposure were observed after the ocular instillation of 8-oxo-dG in rabbits. These PK profiles are favorable for the treatment of ocular surface diseases. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MARY ANN LIEBERT, INC | - |
dc.relation.isPartOf | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS | - |
dc.title | Ocular Distribution and Pharmacokinetics of 8-Oxo-2 '-Deoxyguanosine: A Novel Therapeutic Candidate of Ocular Surface Diseases | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000877670900004 | - |
dc.identifier.doi | 10.1089/jop.2022.0054 | - |
dc.identifier.bibliographicCitation | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS, v.38, no.8, pp.561 - 566 | - |
dc.description.isOpenAccess | N | - |
dc.identifier.scopusid | 2-s2.0-85140812297 | - |
dc.citation.endPage | 566 | - |
dc.citation.startPage | 561 | - |
dc.citation.title | JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS | - |
dc.citation.volume | 38 | - |
dc.citation.number | 8 | - |
dc.contributor.affiliatedAuthor | Ha, Yuseung | - |
dc.contributor.affiliatedAuthor | Kim, Yong Ho | - |
dc.contributor.affiliatedAuthor | Shin, Dongseong | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | 8-oxo-dG | - |
dc.subject.keywordAuthor | RCI001 | - |
dc.subject.keywordAuthor | ocular pharmacokinetics | - |
dc.subject.keywordAuthor | inflammation | - |
dc.subject.keywordPlus | DRUG-DELIVERY | - |
dc.subject.keywordPlus | STRESS | - |
dc.subject.keywordPlus | DAMAGE | - |
dc.relation.journalResearchArea | Ophthalmology | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Ophthalmology | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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