Glutathione Fluorescence Sensing Based on a Co-Doped Carbon Dot/Manganese Dioxide Nanocoral Composite
- Authors
- Le, Thi-Hoa; Lee, Hyun-Jong; Tran, Quang-Nhat
- Issue Date
- Dec-2022
- Publisher
- MDPI
- Keywords
- fluorescence resonance energy transfer (FRET); Glutathione; NPCD-MnO2 nanocoral composite; “turn on” fluorescence
- Citation
- Materials, v.15, no.23
- Journal Title
- Materials
- Volume
- 15
- Number
- 23
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86314
- DOI
- 10.3390/ma15238677
- ISSN
- 1996-1944
- Abstract
- Glutathione (GSH) is an antioxidant thiol that has a vital role in the pathogenesis of various human diseases such as cardiovascular disease and cancer. Hence, it is necessary to study effective methods of GSH evaluation. In our work, an effective GSH sensor based on a nitrogen and phosphorus co-doped carbon dot (NPCD)-MnO2 nanocoral composite was fabricated. In addition to utilizing the strong fluorescence of the NPCDs, we utilized the reductant ability of the NPCDs themselves to form MnO2 and then the NPCD-MnO2 nanocoral composite from MnO4−. The characteristics of the nanocoral composite were analyzed using various electron microscopy techniques and spectroscopic techniques. The overlap between the absorption spectrum of MnO2 and the fluorescence emission spectrum of the NPCDs led to effective fluorescence resonance energy transfer (FRET) in the nanocoral composite, causing a decrease in the fluorescent intensity of the NPCDs. A linear recovery of the fluorescent intensity of the NPCDs was observed with the GSH level raising from 20 to 250 µM. Moreover, our GSH sensor showed high specificity and sensing potential in real samples with acceptable results.
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