Bone Regeneration Using a Mixture of Silicon-Substituted Coral HA and beta-TCP in a Rat Calvarial Bone Defect Model
- Authors
- Roh, Jiyeon; Kim, Ji-Youn; Choi, Young-Muk; Ha, Seong-Min; Kim, Kyoung-Nam; Kim, Kwang-Mahn
- Issue Date
- Feb-2016
- Publisher
- MDPI AG
- Keywords
- silicon-substituted coral hydroxyapatite; beta-tricalcium phosphate; bone graft material; bone regeneration; rat calvarial bone defect model
- Citation
- MATERIALS, v.9, no.2
- Journal Title
- MATERIALS
- Volume
- 9
- Number
- 2
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8647
- DOI
- 10.3390/ma9020097
- ISSN
- 1996-1944
- Abstract
- The demand of bone graft materials has been increasing. Among various origins of bone graft materials, natural coral composed of up to 99% calcium carbonate was chosen and converted into hydroxyapatite (HA); silicon was then substituted into the HA. Then, the Si-HA was mixed with -tricalcium phosphate (TCP) in the ratios 100:0 (S100T0), 70:30 (S70T30), 60:40 (S60T40), and 50:50 (S50T50). The materials were implanted for four and eight weeks in a rat calvarial bone defect model (8 mm). The MBCPTM (HA:-TCP = 60:40, Biomatalante, Vigneux de Bretagne, France) was used as a control. After euthanasia, the bone tissue was analyzed by making histological slides. From the results, S60T40 showed the fastest bone regeneration in four weeks (p < 0.05). In addition, S60T40, S50T50, and MBCPTM showed significant new bone formation in eight weeks (p < 0.05). In conclusion, Si-HA/TCP showed potential as a bone graft material.
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