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Isolation of bioactive biphenyl compounds from the twigs of Chaenomeles sinensis
- Authors
- Kim, Chung Sub; Subedi, Lalita; Kwon, Oh Kil; Kim, Sun Yeou; Yeo, Eui-Ju; Choi, Sang Un; Lee, Kang Ro
- Issue Date
- 15-Jan-2016
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Chaenomeles sinensis; Biphenyl compounds; Cytotoxicity; Anti-inflammation; NGF-potentiation
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.26, no.2, pp.351 - 354
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 26
- Number
- 2
- Start Page
- 351
- End Page
- 354
- ISSN
- 0960-894X
- Abstract
- Investigation of the MeOH extract of Chaenomeles sinensis twigs resulted in the isolation of seven biphenyl compounds (1-7) including a new compound, chaenomin (1). The chemical structures of the isolated compounds were elucidated by extensive NMR data (H-1 and C-13 NMR, H-1-H-1 COSY, HSQC and HMBC), specific optical rotation, and chemical reaction. Compounds 2 and 6 showed potent cytotoxic activities against four cancer cell lines (A549, SK-OV-3, SK-MEL-2, and HCT15), and compound 7 exhibited potent anti-neuroinflammatory and NGF-potentiating activity. (C) 2015 Elsevier Ltd. All rights reserved.
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Related Researcher
- Kim, Sun Yeou
- Pharmacy (Dept.of Pharmacy)