Emergence of exosomal miRNAs as a diagnostic biomarker for Alzheimer's disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Van Giau, Vo | - |
dc.contributor.author | An, Seong Soo A. | - |
dc.date.available | 2020-02-28T03:41:45Z | - |
dc.date.created | 2020-02-06 | - |
dc.date.issued | 2016-01-15 | - |
dc.identifier.issn | 0022-510X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8673 | - |
dc.description.abstract | Alzheimer's disease (AD) is the most common progressive degenerative disorder, and is characterized by memory loss and cognitive decline. It is a complex disorder with both environmental and genetic components. Current diagnosis of AD is based primarily on the analysis of the patient's cognitive function using imaging techniques and the biochemical analyses of bodily fluids. Efforts have been made to develop not only an effective therapeutic, but also a diagnostic capable of identifying AD before the onset of irreversible neurological damage. The molecular content of exosomes is a fingerprint of the releasing cell type and its status. A significant body of literature has demonstrated that molecular constituents of exosomes, especially exosomal proteins and microRNAs (miRNAs), hold great promise as novel biomarkers for clinical diagnosis. In addition, expression profiling of miRNAs found in nanovesicles has revealed diagnostic potential in neurodegenerative diseases. Currently, exosomal miRNAs within biological fluids are known as good disease-related markers, and have emerged as a powerful tool for solving many difficulties in both the diagnosis and treatment of AD patients. In this review, we reviewed recent advances in the research of exosomal biomarkers as well as exosomal miRNAs, summarized of actively used approaches to identifying potential miRNA biomarkers through mouse models and their potential application in clinical diagnostics in AD. We also supply a comprehensive overview of the formation, function, and isolation of exosomes. (C) 2015 Elsevier B.V. All rights reserved. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE BV | - |
dc.relation.isPartOf | JOURNAL OF THE NEUROLOGICAL SCIENCES | - |
dc.subject | CELL-DERIVED EXOSOMES | - |
dc.subject | HUMAN URINARY EXOSOMES | - |
dc.subject | COMPLEX CLASS-II | - |
dc.subject | MICRORNA EXPRESSION | - |
dc.subject | NEURODEGENERATIVE DISEASES | - |
dc.subject | TRANSFERRIN RECEPTOR | - |
dc.subject | CEREBROSPINAL-FLUID | - |
dc.subject | PREFRONTAL CORTEX | - |
dc.subject | MESSENGER-RNAS | - |
dc.subject | CSF BIOMARKERS | - |
dc.title | Emergence of exosomal miRNAs as a diagnostic biomarker for Alzheimer's disease | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000369681100031 | - |
dc.identifier.doi | 10.1016/j.jns.2015.12.005 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE NEUROLOGICAL SCIENCES, v.360, pp.141 - 152 | - |
dc.identifier.scopusid | 2-s2.0-84955516883 | - |
dc.citation.endPage | 152 | - |
dc.citation.startPage | 141 | - |
dc.citation.title | JOURNAL OF THE NEUROLOGICAL SCIENCES | - |
dc.citation.volume | 360 | - |
dc.contributor.affiliatedAuthor | Van Giau, Vo | - |
dc.contributor.affiliatedAuthor | An, Seong Soo A. | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | miRNAs | - |
dc.subject.keywordAuthor | Biomarkers | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | Diagnostic | - |
dc.subject.keywordAuthor | Nanovesicles | - |
dc.subject.keywordPlus | CELL-DERIVED EXOSOMES | - |
dc.subject.keywordPlus | HUMAN URINARY EXOSOMES | - |
dc.subject.keywordPlus | COMPLEX CLASS-II | - |
dc.subject.keywordPlus | MICRORNA EXPRESSION | - |
dc.subject.keywordPlus | NEURODEGENERATIVE DISEASES | - |
dc.subject.keywordPlus | TRANSFERRIN RECEPTOR | - |
dc.subject.keywordPlus | CEREBROSPINAL-FLUID | - |
dc.subject.keywordPlus | PREFRONTAL CORTEX | - |
dc.subject.keywordPlus | MESSENGER-RNAS | - |
dc.subject.keywordPlus | CSF BIOMARKERS | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
1342, Seongnam-daero, Sujeong-gu, Seongnam-si, Gyeonggi-do, Republic of Korea(13120)031-750-5114
COPYRIGHT 2020 Gachon University All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.