Subtle Cognitive Deficits Are Associated with Amyloid-beta Positivity, but Not Severity of Self-Reported Decline: Results from the CoSCo Studyopen access
- Authors
- Ryu, Seon Young; Hong, Yun Jeong; Ho, SeongHee; Jeong, Jee Hyang; Park, Kee Hyung; Kim, SangYun; Wang, Min Jeong; Choi, Seong Hye; Yang, Dong Won
- Issue Date
- Jun-2022
- Publisher
- KARGER
- Keywords
- Subjective cognitive decline; Subtle cognitive impairment; Amyloid-beta; Alzheimer' s disease
- Citation
- DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, v.51, no.2, pp.159 - 167
- Journal Title
- DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
- Volume
- 51
- Number
- 2
- Start Page
- 159
- End Page
- 167
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86829
- DOI
- 10.1159/000523971
- ISSN
- 1420-8008
- Abstract
- Introduction: Subjective cognitive decline (SCD) can be considered as the preclinical manifestation of Alzheimer's disease (AD). The National Institute on Aging and the Alzheimer's Association criteria for preclinical AD proposed that subtle cognitive changes appear along with AD biomarkers in the late stage of preclinical AD. The objective of this study was to explore whether subtle cognitive impairment (SCI) in individuals with SCD is associated with brain amyloid-beta (A beta) status and SCD severity. Methods: One hundred twenty individuals with SCD (mean age: 70.87 +/- 6.10 years) were included in this study. SCI was defined as performance <= -1.0 SD on at least two neuropsychological tests. Participants underwent an amyloid positron emission tomography, which was assessed visually and quantitatively using standardized uptake value ratio (SUVR). The severity of SCD was assessed using two self-reported questionnaires: the SCD questionnaire based on the SCD-plus features and the Korean-Everyday Cognition (K-ECog) scale. Results: SCD individuals with SCI (n = 25) had more A beta positivity than the SCD only group (n = 95) (44% vs. 15.79%; p = 0.002). In addition, the SCI group had a higher global SUVR than the SCD only group (p = 0.048). For self-reported questionnaires, there were no differences in SCD questionnaire total scores and K-ECog global and cognitive domain-specific scores between two groups. Conclusions: In SCD individuals, SCI was associated with higher A beta positivity, but not with the severity of self-reported cognitive decline, compared to the SCD only group. These results suggest that the recognition of objectively defined subtle cognitive deficits may contribute to the early identification of AD in SCD. (C) 2022 The Author(s). Published by S. Karger AG, Basel
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의학과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/86829)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.