Construction of ultrasensitive electrochemical sensor using TiO2-reduced graphene oxide nanofibers nanocomposite for epinephrine detection

Abstract

A facile sensing platform was established for the electrochemical detection of epinephrine using titanium dioxide-reduced graphene oxide nanofibers (TiO2-rGO NFs) nanocomposite modified glassy carbon electrode. The TiO2-rGO NFs were prepared using electrospinning followed by hydrothermal method, characterized by various state-of-the-art techniques, and the fabricated sensor were characterized by cyclic voltammetry and differential pulse voltammetry. Using the optimal experimental conditions potential scan rate, linear correlation between analytical signal and concentration of 10-100 nM with a detection limit of 8.11 nM, and sensitivity 0.126 mu A mu M-1 were observed. The constructed sensor were evaluated the sensing of epinephrine in human serum and drug injection samples. The developed electrochemical sensor provides a potential candidate for the accurate sensing of epinephrine in biological fluids and pharmaceutical drugs.