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Neonatal Deafening Selectively Degrades the Sensitivity to Interaural Time Differences of Electrical Stimuli in Low-Frequency Pathways in Ratsopen access

Authors
Sunwoo, Woongsang
Issue Date
Jan-2023
Publisher
SOC NEUROSCIENCE
Keywords
auditory deprivation; binaural hearing; cochlear implant; development; inferior colliculus; interaural time difference
Citation
ENEURO, v.10, no.1
Journal Title
ENEURO
Volume
10
Number
1
URI
https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87077
DOI
10.1523/ENEURO.0437-22.2022
ISSN
2373-2822
Abstract
We examined the effect of neonatal deafening on frequency-specific pathways for processing of interaural time differences (ITDs) in cochlear-implant stimuli. Animal studies have demonstrated differences in neural ITD sensitivity in the inferior colliculus (IC) depending on the intracochlear location of intracochlear stimulating electrodes. We used neonatally deafened (ND) rats of both sexes and recorded the responses of single neu-rons in the IC to electrical stimuli with ITDs delivered to the apical or basal cochlea and compared them with acutely deafened (AD) rats of both sexes with normal hearing (NH) during development. We found that neona -tal deafness significantly impacted the ITD sensitivity and the ITD tuning patterns restricted to apically driven IC neurons. In ND rats, the ITD sensitivity of apically driven neurons is reduced to values similar to basally driven neurons. The prevalence of ITD-sensitive apical neurons with a peak-shaped ITD tuning curve, which may reflect predominant input from the medial superior olivary (MSO) complex, in ND rats was diminished compared with that in AD rats (67%, AD vs 40%, ND). Conversely, monotonic-type responses rarely occurred in AD rats (14%) but were approximately equally as prevalent as peak-type tuning curves in ND rats (42%). Nevertheless, in ND rats, the ITD at the maximum slope of the ITD tuning curve was still more concentrated within the physiological ITD range in apically driven than in basally driven neurons. These results indicate that the development of high ITD sensitivity processed by low-frequency pathways depends on normal auditory ex-perience and associated biases in ITD tuning strategies.
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College of Medicine (Department of Medicine)
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