급성 진행성 사구체신염을 동반한 eosinophilic granulomatosis with polyangiitis 1예Eosinophilic granulomatosis with polyangiitis accompanied by rapidly progressive glomerulonephritis
- Other Titles
- Eosinophilic granulomatosis with polyangiitis accompanied by rapidly progressive glomerulonephritis
- Authors
- Kim, Sojeong; Lee, Sang Min; Shim, Young Sup; Ahn, Jeong Yeal; Lee, Sangho; Ha, Seung Heon; Lee, Sang Pyo
- Issue Date
- Jan-2016
- Publisher
- KOREAN ACAD ASTHMA ALLERGY & CLINICAL IMMUNOLOGY
- Keywords
- Churg-Strauss syndrome; Eosinophilic granulomatosis with polyangiitis; Rapidly progressive glomerulonephritis; Kidney injury
- Citation
- ALLERGY ASTHMA & RESPIRATORY DISEASE, v.4, no.1, pp.70 - 73
- Journal Title
- ALLERGY ASTHMA & RESPIRATORY DISEASE
- Volume
- 4
- Number
- 1
- Start Page
- 70
- End Page
- 73
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8749
- DOI
- 10.4168/aard.2016.4.1.70
- ISSN
- 2288-0402
- Abstract
- Eosinophilic granulomatosis with polyangitis (EGPA) should be considered in asthmatic patients who present with severe systemic symptoms and eosinophilia. Progressive renal insufficiency can occur during the acute phase of EGPA accompanied by renovascular involvement. A 58-year-old man visited local clinic with complaints of malaise, weight loss, fever, and dyspnea. Eosinophilia was revealed in peripheral blood. Pulmonary function tests were carried out, which yielded decreased lung function with positive bronchodilator response. Kidney and skin biopsies were performed, and histological examination showed acute necrotizing crescentic glomerulonephritis and leukoclastic vasculitis in the skin, which led to a diagnosis of EGPA (Churg-Strauss syndrome) associated with rapidly progressive glomerulonephritis. The patient received pulse steroid therapy with parenteral methylprednisolone, followed by oral prednisolone. Clinical and laboratory findings improved dramatically, and remission was attained rapidly. The patient continued to be in remission for 5 months. Prompt and aggressive treatment with systemic corticosteroids is mandatory to control disease activity and to achieve remission.
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