Elucidation of Phytochemicals Affecting Platelet Responsiveness in Dangguisu-san: Active Ingredient Prediction and Experimental Research Using Network Pharmacologyopen access
- Authors
- Lee, Dong-Ha; Kwak, Hee Jae; Shin, Yonghee; Kim, Sung Jin; Lee, Ga Hee; Park, Il-Ho; Kim, Seung Hyun; Kang, Ki Sung
- Issue Date
- Mar-2023
- Publisher
- MDPI
- Keywords
- phytochemicals; platelet; active ingredient; network pharmacology
- Citation
- PLANTS-BASEL, v.12, no.5
- Journal Title
- PLANTS-BASEL
- Volume
- 12
- Number
- 5
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87592
- DOI
- 10.3390/plants12051120
- ISSN
- 2223-7747
- Abstract
- Plant-derived phytochemicals are emerging as novel agents for protection against chronic disorders. Dangguisu-san is a herbal prescription to invigorate the blood and relieve pain. Among the numerous active constituents of Dangguisu-san, those expected to be effective at inhibiting platelet aggregation were predicted using a network pharmacological method, and their efficacy was experimentally demonstrated. All four identified chemical components, namely chrysoeriol, apigenin, luteolin, and sappanchalcone, suppressed the aggregation of platelets to a certain extent. However, we report, for the first time, that chrysoeriol acts as a strong inhibitor of platelet aggregation. Although additional in vivo studies are needed, among the complex constituents of herbal medicines, the components that exert an inhibitory effect on platelet aggregation were predicted using a network pharmacological method and experimentally confirmed with human platelets.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 한의과대학 > 한의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87592)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.