Recent Advances in Molecular and Immunological Diagnostic Platform for Virus Detection: A Reviewopen access
- Authors
- Trinh, Kieu The Loan; Do, Hoang Dang Khoa; Lee, Nae Yoon
- Issue Date
- Apr-2023
- Publisher
- MDPI
- Keywords
- microfluidics; virus; immunoassay; molecular assay
- Citation
- BIOSENSORS-BASEL, v.13, no.4
- Journal Title
- BIOSENSORS-BASEL
- Volume
- 13
- Number
- 4
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87684
- DOI
- 10.3390/bios13040490
- ISSN
- 2079-6374
- Abstract
- Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused an ongoing coronavirus disease (COVID-19) outbreak and a rising demand for the development of accurate, timely, and cost-effective diagnostic tests for SARS-CoV-2 as well as other viral infections in general. Currently, traditional virus screening methods such as plate culturing and real-time PCR are considered the gold standard with accurate and sensitive results. However, these methods still require sophisticated equipment, trained personnel, and a long analysis time. Alternatively, with the integration of microfluidic and biosensor technologies, microfluidic-based biosensors offer the ability to perform sample preparation and simultaneous detection of many analyses in one platform. High sensitivity, accuracy, portability, low cost, high throughput, and real-time detection can be achieved using a single platform. This review presents recent advances in microfluidic-based biosensors from many works to demonstrate the advantages of merging the two technologies for sensing viruses. Different platforms for virus detection are classified into two main sections: immunoassays and molecular assays. Moreover, available commercial sensing tests are analyzed.
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