Honeyberry-derived carbon quantum dots ameliorate LPS-induced neuroinflammation and oxidative stress through Nrf2/HO-1 signalling in HMC3 cells
DC Field | Value | Language |
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dc.contributor.author | Sanjay, Sanjay | - |
dc.contributor.author | Sharma, Anshul | - |
dc.contributor.author | Lee, Hae-Jeung | - |
dc.date.accessioned | 2023-05-17T02:52:21Z | - |
dc.date.available | 2023-05-17T02:52:21Z | - |
dc.date.created | 2023-05-08 | - |
dc.date.issued | 2023-12 | - |
dc.identifier.issn | 2169-1401 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/87852 | - |
dc.description.abstract | Carbon quantum dots (CQDs) were synthesized from blue honeysuckle (Lonicera caerulea) berry fruit extracts using a well-known, cost-effective, and environmental friendly hydrothermal process. The material was characterized using UV-vis spectroscopy, photoluminescence (PL), XPS, and TEM studies. The as -synthesized carbon dots exhibit excellent PL properties, with a quantum yield of -35.92%. CQDs vary in size from -2 nm to 9 nm. This study established the neuroprotective effects of CQDs against lipopolysaccharide (LPS)-induced human microglial cell model. LPS was found to induce cytotoxicity, reactive oxygen species, and pro-inflammatory cytokines interleukin (IL)-113, IL-6, and tumour necrosis factor -a) and downregulated enzymatic antioxidants such as nuclear factor-erythroid factor 2-related factor 2 (Nrf2), superoxide dismutase, catalase, haem oxygenase (HO)-1, HO-2, and glutathione peroxidase, while CQDs treatment reversed LPS induced cytotoxicity, induced anti-inflammatory cytokines (IL-4, IL-10, and transforming growth factor 13) and induce enzymatic antioxidants both at transcriptional and translational levels. The study suggested the potential role of CQDs prepared from Lonicera caerulea, as anti-inflammatory and antioxidative agents in neuroinflammatory and neurodegenerative diseases. In addition, CQDs could be exploited in various biomedical applications such as biosensing, drug delivery and tissue engineering. <br />[GRAPHICAL ABSTRACT] | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.relation.isPartOf | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | - |
dc.title | Honeyberry-derived carbon quantum dots ameliorate LPS-induced neuroinflammation and oxidative stress through Nrf2/HO-1 signalling in HMC3 cells | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000937093700001 | - |
dc.identifier.doi | 10.1080/21691401.2023.2179062 | - |
dc.identifier.bibliographicCitation | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, v.51, no.1, pp.95 - 107 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85148657400 | - |
dc.citation.endPage | 107 | - |
dc.citation.startPage | 95 | - |
dc.citation.title | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | - |
dc.citation.volume | 51 | - |
dc.citation.number | 1 | - |
dc.contributor.affiliatedAuthor | Sanjay, Sanjay | - |
dc.contributor.affiliatedAuthor | Sharma, Anshul | - |
dc.contributor.affiliatedAuthor | Lee, Hae-Jeung | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Carbon quantum dots | - |
dc.subject.keywordAuthor | Lonicera caerulea | - |
dc.subject.keywordAuthor | lipopolysaccharide | - |
dc.subject.keywordAuthor | antioxidant | - |
dc.subject.keywordAuthor | anti-inflammation | - |
dc.subject.keywordPlus | HEME OXYGENASE SYSTEM | - |
dc.subject.keywordPlus | GREEN SYNTHESIS | - |
dc.subject.keywordPlus | ANTIOXIDANT ACTIVITY | - |
dc.subject.keywordPlus | REACTIVE OXYGEN | - |
dc.subject.keywordPlus | IN-VIVO | - |
dc.subject.keywordPlus | NRF2 | - |
dc.relation.journalResearchArea | Biotechnology & Applied Microbiology | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Biotechnology & Applied Microbiology | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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