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The therapeutic effects on U87 and SAS cells using Proton Linac based Boron Neutron Capture Therapy in Korea
- Authors
- Seo, Il Hyeok; Seo, Hyo Jung; Na, Dasom; Yoo, Mooyoung; Schwint, Amanda; Kim, Se Hyun; Lee, Jeongwoo; Jeon, Sang-June; Choi, Jae Won; Kim, Woo Hyoung; Park, Kawngwoo; Yee, Gi-Taek; Kim, Woo-Kyung
- Issue Date
- Jul-2023
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Citation
- APPLIED RADIATION AND ISOTOPES, v.197
- Journal Title
- APPLIED RADIATION AND ISOTOPES
- Volume
- 197
- ISSN
- 0969-8043
- Abstract
- A proton linac based boron neutron capture therapy system (A-BNCT, 10MeV, 4mA) was successfully developed in Korea. We performed in vitro experiments with U87 and SAS cells and revealed the efficacy of a binary therapy BNCT using epithermal neutrons and boronophenylalanine (BPA). The results revealed that BNCT showed cancer cell selectivity and caused cell death. Further in vitro studies can be a valuable method to characterize an A-BNCT system. We expect BNCT to become a treatment option for cancer patients.
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