Targeting Nociceptive Neurons and Transient Receptor Potential Channels for the Treatment of Migraine
DC Field | Value | Language |
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dc.contributor.author | Cohen, Cinder Faith | - |
dc.contributor.author | Roh, Jueun | - |
dc.contributor.author | Lee, Sang Hoon | - |
dc.contributor.author | Park, Chul-Kyu | - |
dc.contributor.author | Berta, Temugin | - |
dc.date.accessioned | 2023-06-11T02:41:33Z | - |
dc.date.available | 2023-06-11T02:41:33Z | - |
dc.date.created | 2023-05-30 | - |
dc.date.issued | 2023-04 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88060 | - |
dc.description.abstract | Migraine is a neurovascular disorder that affects approximately 12% of the global population. While its exact causes are still being studied, researchers believe that nociceptive neurons in the trigeminal ganglia play a key role in the pain signals of migraine. These nociceptive neurons innervate the intracranial meninges and convey pain signals from the meninges to the thalamus. Targeting nociceptive neurons is considered promising due to their accessibility and distinct molecular profile, which includes the expression of several transient receptor potential (TRP) channels. These channels have been linked to various pain conditions, including migraine. This review discusses the role and mechanisms of nociceptive neurons in migraine, the challenges of current anti-migraine drugs, and the evidence for well-studied and emerging TRP channels, particularly TRPC4, as novel targets for migraine prevention and treatment. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.title | Targeting Nociceptive Neurons and Transient Receptor Potential Channels for the Treatment of Migraine | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 000986812800001 | - |
dc.identifier.doi | 10.3390/ijms24097897 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.24, no.9 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85159330749 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 24 | - |
dc.citation.number | 9 | - |
dc.contributor.affiliatedAuthor | Roh, Jueun | - |
dc.contributor.affiliatedAuthor | Park, Chul-Kyu | - |
dc.type.docType | Review | - |
dc.subject.keywordAuthor | migraine | - |
dc.subject.keywordAuthor | headache | - |
dc.subject.keywordAuthor | peripheral sensory neurons | - |
dc.subject.keywordAuthor | transient receptor potential channels | - |
dc.subject.keywordAuthor | TRPC4 | - |
dc.subject.keywordAuthor | CGRP | - |
dc.subject.keywordPlus | CORTICAL SPREADING DEPRESSION | - |
dc.subject.keywordPlus | GENOME-WIDE ASSOCIATION | - |
dc.subject.keywordPlus | GENE-RELATED PEPTIDE | - |
dc.subject.keywordPlus | PRIMARY AFFERENT NEURONS | - |
dc.subject.keywordPlus | PRIMARY SENSORY NEURONS | - |
dc.subject.keywordPlus | ION-CHANNEL | - |
dc.subject.keywordPlus | TRP CHANNELS | - |
dc.subject.keywordPlus | TRIGEMINOVASCULAR SYSTEM | - |
dc.subject.keywordPlus | MENINGEAL NOCICEPTORS | - |
dc.subject.keywordPlus | SUSCEPTIBILITY LOCI | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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