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Targeting Nociceptive Neurons and Transient Receptor Potential Channels for the Treatment of Migraine

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dc.contributor.authorCohen, Cinder Faith-
dc.contributor.authorRoh, Jueun-
dc.contributor.authorLee, Sang Hoon-
dc.contributor.authorPark, Chul-Kyu-
dc.contributor.authorBerta, Temugin-
dc.date.accessioned2023-06-11T02:41:33Z-
dc.date.available2023-06-11T02:41:33Z-
dc.date.created2023-05-30-
dc.date.issued2023-04-
dc.identifier.issn1661-6596-
dc.identifier.urihttps://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88060-
dc.description.abstractMigraine is a neurovascular disorder that affects approximately 12% of the global population. While its exact causes are still being studied, researchers believe that nociceptive neurons in the trigeminal ganglia play a key role in the pain signals of migraine. These nociceptive neurons innervate the intracranial meninges and convey pain signals from the meninges to the thalamus. Targeting nociceptive neurons is considered promising due to their accessibility and distinct molecular profile, which includes the expression of several transient receptor potential (TRP) channels. These channels have been linked to various pain conditions, including migraine. This review discusses the role and mechanisms of nociceptive neurons in migraine, the challenges of current anti-migraine drugs, and the evidence for well-studied and emerging TRP channels, particularly TRPC4, as novel targets for migraine prevention and treatment.-
dc.language영어-
dc.language.isoen-
dc.publisherMDPI-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.titleTargeting Nociceptive Neurons and Transient Receptor Potential Channels for the Treatment of Migraine-
dc.typeArticle-
dc.type.rimsART-
dc.description.journalClass1-
dc.identifier.wosid000986812800001-
dc.identifier.doi10.3390/ijms24097897-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.24, no.9-
dc.description.isOpenAccessY-
dc.identifier.scopusid2-s2.0-85159330749-
dc.citation.titleINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES-
dc.citation.volume24-
dc.citation.number9-
dc.contributor.affiliatedAuthorRoh, Jueun-
dc.contributor.affiliatedAuthorPark, Chul-Kyu-
dc.type.docTypeReview-
dc.subject.keywordAuthormigraine-
dc.subject.keywordAuthorheadache-
dc.subject.keywordAuthorperipheral sensory neurons-
dc.subject.keywordAuthortransient receptor potential channels-
dc.subject.keywordAuthorTRPC4-
dc.subject.keywordAuthorCGRP-
dc.subject.keywordPlusCORTICAL SPREADING DEPRESSION-
dc.subject.keywordPlusGENOME-WIDE ASSOCIATION-
dc.subject.keywordPlusGENE-RELATED PEPTIDE-
dc.subject.keywordPlusPRIMARY AFFERENT NEURONS-
dc.subject.keywordPlusPRIMARY SENSORY NEURONS-
dc.subject.keywordPlusION-CHANNEL-
dc.subject.keywordPlusTRP CHANNELS-
dc.subject.keywordPlusTRIGEMINOVASCULAR SYSTEM-
dc.subject.keywordPlusMENINGEAL NOCICEPTORS-
dc.subject.keywordPlusSUSCEPTIBILITY LOCI-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
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