Targeting Nociceptive Neurons and Transient Receptor Potential Channels for the Treatment of Migraineopen access
- Authors
- Cohen, Cinder Faith; Roh, Jueun; Lee, Sang Hoon; Park, Chul-Kyu; Berta, Temugin
- Issue Date
- Apr-2023
- Publisher
- MDPI
- Keywords
- migraine; headache; peripheral sensory neurons; transient receptor potential channels; TRPC4; CGRP
- Citation
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.24, no.9
- Journal Title
- INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Volume
- 24
- Number
- 9
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88060
- DOI
- 10.3390/ijms24097897
- ISSN
- 1661-6596
- Abstract
- Migraine is a neurovascular disorder that affects approximately 12% of the global population. While its exact causes are still being studied, researchers believe that nociceptive neurons in the trigeminal ganglia play a key role in the pain signals of migraine. These nociceptive neurons innervate the intracranial meninges and convey pain signals from the meninges to the thalamus. Targeting nociceptive neurons is considered promising due to their accessibility and distinct molecular profile, which includes the expression of several transient receptor potential (TRP) channels. These channels have been linked to various pain conditions, including migraine. This review discusses the role and mechanisms of nociceptive neurons in migraine, the challenges of current anti-migraine drugs, and the evidence for well-studied and emerging TRP channels, particularly TRPC4, as novel targets for migraine prevention and treatment.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 의과대학 > 의예과 > 1. Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/88060)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.