Nanotechnology-Based Promising Therapeutic Approaches Against Protozoan

Abstract

Protozoan-borne diseases are major drivers of global morbidities and mortalities, especially in developing countries. These diseases pose a unique challenge to effective treatment strategies, thereby contributing to significant death. Current treatment approaches have low efficacy, high toxicity and side effects of therapeutic doses and therefore generate a need for alternative new treatment approaches. Nanotechnology-based drug delivery systems have evolved as a new and promising approach to therapy and prevention of protozoan-associated infectious diseases. The formulation of new drugs and drugs’ carriers using nano-sized particles including exosomes, liposomes, solid lipid nanoparticles, dendrimers and nano-vaccines promises to overcome the limitations of low bioavailability, low toxicity, sub-therapeutic drug accumulation in microbial sanctuaries and reservoirs and low patient adherence due to drug-related toxicities and extended therapeutic regimens. Nanotechnology-based therapeutic approaches offer an important weapon in the fight against infectious protozoan diseases. © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023.