Eosinophils and type 2 cytokine signaling in macrophages support the biogenesis of cold-induced beige fat
- Authors
- Jung, Y.
- Issue Date
- Mar-2016
- Publisher
- The Korean Society for Mocrobiology / The Korean Society of Virology
- Keywords
- Beige fat; Brown adipose tissue; Eosinophil; Thermogenesis; Type 2 cytokine
- Citation
- Journal of Bacteriology and Virology, v.46, no.1, pp.44 - 46
- Journal Title
- Journal of Bacteriology and Virology
- Volume
- 46
- Number
- 1
- Start Page
- 44
- End Page
- 46
- URI
- https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/8816
- DOI
- 10.4167/jbv.2016.46.1.44
- ISSN
- 1598-2467
- Abstract
- Brown adipose generates heat via oxidation of fatty acids by a mitochondrial uncoupling protein 1 (UCP1)-dependent process. In addition, a subpopulation of cells within subcutaneous white adipose tissue, known as beige adipocytes, also plays a role in thermogenesis. The biogenesis of beige adipocytes is induced by thermogenic signals, such as chronic cold exposure. Recently, it has been reported that eosinophils, type 2 cytokines of IL-4/13, and alternatively activated macrophages control the thermogenic cycle of beige adipocytes. Alternatively, activated macrophages induce UCP1+ beige adipocytes through secretion of catecholamines. These results define the role of type 2 immune responses in the regulation of energy homeostasis. © 2016, Chonnam National University Medical School. All rights reserved.
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