Severe coronavirus disease 2019 in pediatric solid organ transplant recipients: Big data convergence study in Korea (K-COV-N cohort)
DC Field | Value | Language |
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dc.contributor.author | Kang, Ji-Man | - |
dc.contributor.author | Kang, Minsun | - |
dc.contributor.author | Kim, Young-Eun | - |
dc.contributor.author | Choi, Yoonkyung | - |
dc.contributor.author | An, Soo Jeong | - |
dc.contributor.author | Seong, Jaehyun | - |
dc.contributor.author | Go, Min Jin | - |
dc.contributor.author | Huh, Kyungmin | - |
dc.contributor.author | Jung, Jaehun | - |
dc.date.accessioned | 2023-09-01T16:40:43Z | - |
dc.date.available | 2023-09-01T16:40:43Z | - |
dc.date.created | 2023-08-29 | - |
dc.date.issued | 2023-09 | - |
dc.identifier.issn | 1201-9712 | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gachon/handle/2020.sw.gachon/89020 | - |
dc.description.abstract | Objectives: The risk of severe COVID-19 in children with a solid organ transplant (SOT) is not well es-tablished. We compare the relative risk of severe COVID-19 infection between pediatric SOT and non-SOT children.Methods: The newly constructed K-COV-N cohort (Korea Disease Control and Prevention Agency-COVID-19-National Health Insurance Service) was used. Children with COVID-19 ( < 18 years old) who under-went SOT between January 2008 to January 2022 were included. Non-SOT children with COVID-19 were selected in a ratio of 1:4 using propensity score matching. Three definitions of severe COVID-19 were established based on their requirement for respiratory support: severe I (requiring respiratory support above a high-flow nasal cannula or prolonged hospitalization & GE;6 days), severe II (requiring any oxygen supplement), and severe III (requiring any oxygen supplement or prolonged hospitalization & GE;6 days).Results: Among 2,957,323 children with COVID-19, 206 pediatric SOT recipients (SOTRs) were identified and included in the analysis along with 803 matched non-SOT children. Most infections (96.6%) occurred during the Omicron period; no cases of mortality were reported. Pediatric SOTR had a 3.6-fold (95% con-fidence interval = 1.1-11.7, P = 0.03) higher risk of severe I, and a 4.9-fold (95% confidence interval = 1.6-15.0, P = 0.006) higher risk of severe III than non-SOT children. No cases of severe II occurred in the non-SOT children. Although not statistically significant, no severe COVID-19 cases were reported in the vaccinated SOT group (0.0% vs 5.7%, P = 0.09 in severe III).Conclusion: Pediatric SOTRs have a significantly higher risk of severe COVID-19 than non-SOT children. Our findings support the need for tailored strategies for these high-risk children.& COPY; 2023 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious Diseases. This is an open access article under the CC BY-NC-ND license ( http://creativecommons.org/licenses/by-nc-nd/4.0/ ) | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | - |
dc.title | Severe coronavirus disease 2019 in pediatric solid organ transplant recipients: Big data convergence study in Korea (K-COV-N cohort) | - |
dc.type | Article | - |
dc.type.rims | ART | - |
dc.description.journalClass | 1 | - |
dc.identifier.wosid | 001049187300001 | - |
dc.identifier.doi | 10.1016/j.ijid.2023.06.016 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, v.134, pp.220 - 227 | - |
dc.description.isOpenAccess | Y | - |
dc.identifier.scopusid | 2-s2.0-85164735287 | - |
dc.citation.endPage | 227 | - |
dc.citation.startPage | 220 | - |
dc.citation.title | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | - |
dc.citation.volume | 134 | - |
dc.contributor.affiliatedAuthor | Kang, Minsun | - |
dc.contributor.affiliatedAuthor | Jung, Jaehun | - |
dc.type.docType | Article | - |
dc.subject.keywordAuthor | Solid organ transplant | - |
dc.subject.keywordAuthor | Children | - |
dc.subject.keywordAuthor | Severe COVID-19 | - |
dc.subject.keywordAuthor | Relative risk | - |
dc.subject.keywordAuthor | Korea | - |
dc.subject.keywordPlus | COVID-19 | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
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